Share this article on:

GB virus C infection and B-cell, natural killer cell, and monocyte activation markers in HIV-infected individuals

Stapleton, Jack T.a,b; Martinson, Jeffrey A.c; Klinzman, Donnaa; Xiang, Jinhuaa,b; Desai, Seema N.c; Landay, Alanc,d

doi: 10.1097/QAD.0b013e328363089f
Research Letters

GB virus C (GBV-C), a pan-lymphotropic flavivirus capable of persistent infection, is associated with prolonged survival and reduced T-cell activation in HIV-infected patients. GBV-C was associated with reduced CD56brt/CD16 natural killer cell and monocyte activation, and a trend toward reduced B-cell activation by measuring cell surface activation markers or HIV entry coreceptors. The GBV-C association was independent of HIV viral load. Thus, GBV-C may influence non-T-cell immune activation in individuals with HIV infection.

aResearch and Medical Services, Iowa City VA Medical Center

bDepartments of Internal Medicine and Microbiology, The University of Iowa, Iowa City

cDepartment of Immunology\Microbiology, Rush University, Chicago, Illinois, USA

dUtrecht Institute of Pharmaceutical Sciences, Utrech University, The Netherlands.

Correspondence to Jack T. Stapleton, MD, SW54, GH, 200 Hawkins Drive, Iowa City, IA 52242, USA. Tel: +1 319 356 3168; fax: +1 319 356 4600; e-mail:

Received 24 March, 2013

Revised 6 May, 2013

Accepted 7 May, 2013

© 2013 Lippincott Williams & Wilkins, Inc.