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Adipokines and vascular health in treated HIV infection: an obesity paradox?

Longenecker, Chris T.a,b; Dunn, Whitneyb; Jiang, Yingb; Debanne, Sara M.b; McComsey, Grace A.a,b

doi: 10.1097/QAD.0b013e3283606c11
Research letters

We examined the relationship between plasma adipokine concentrations and ultrasound measures of vascular health in 100 HIV-infected adults on antiretroviral therapy. Leptin was positively correlated with flow-mediated dilation of the brachial artery and negatively with carotid intima–media thickness. These relationships were independent of traditional risk factors and trunk fat in women but not men. Neither adiponectin nor resistin was associated with either measure of vascular health.

aUniversity Hospitals Case Medical Center

bCase Western Reserve University, Cleveland, Ohio, USA.

Correspondence to Grace A. McComsey, MD, Professor of Pediatrics and Medicine, Case Western Reserve University, 11100 Euclid Ave, Cleveland,OH 44106, USA. Tel: +1 216 844 3607; fax: +1 216 844 3926; e-mail:

Received 18 December, 2012

Revised 13 February, 2013

Accepted 20 February, 2013

© 2013 Lippincott Williams & Wilkins, Inc.