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CD3+CD8+CD161high Tc17 cells are depleted in HIV-infection

Gaardbo, Julie Christine; Hartling, Hans Jakob; Thorsteinsson, Kristina; Ullum, Henrik; Nielsen, Susanne Dam

doi: 10.1097/QAD.0b013e32835b8cb3
Research Letters

CD8+ Tc17 cells with pro-inflammatory properties have only recently been acknowledged, and Tc17 cells in HIV-infection are not described. CD3+CD8+CD161high Tc17 cells and the production of interleukin (IL)-17 were examined in untreated and treated HIV-infected patients, HIV–hepatitis C virus co-infected patients, and healthy controls. Depletion of CD3+CD8+CD161high Tc17 cells and diminished production of IL-17 in HIV-infected patients were found. The level of Tc17 cells was associated with the CD4+ cell count in treated patients.

aViro-immunology Research Group, Department of Infectious Diseases, Rigshospitalet, University Hospital of Copenhagen

bDepartment of Clinical Immunology, Rigshospitalet

cDepartment of Infectious Diseases, Hvidovre Hospital, University Hospital of Copenhagen, Denmark.

Correspondence to Susanne Dam Nielsen, MD, DMSc, Department of Infectious Diseases, Rigshospitalet, Blegdamsvej 9B, 2100-Copenhagen, Denmark. E-mail:

Received 30 May, 2012

Revised 3 October, 2012

Accepted 16 October, 2012

Copyright © 2013 Wolters Kluwer Health, Inc.