ObjectiveTo determine the absolute, and proportional prevalence of dual seroreactivity to HIV-1, and HIV-2 in female sex workers in Abidjan, to determine risk determinants for this serologic profile, and to describe the associated clinical, and immunological characteristics.
SettingConfidential clinic for female sex workers in Abidjan.
ParticipantsFemale sex workers.
Main outcome measuresHIV serostatus, CD4+ counts, women with AIDS, behavioural, and sociodemographic characteristics.
ResultsAmong 1209 women tested, the overall HIV seroprevalence was 80%, while the prevalence of dual seroreactivity was 30%. Dual seroreactivity accounted for 38% of all HIV infections. Compared with women reacting to HIV-1 only, dually seroreactive women were significantly more likely to have been in sex work for a longer period, to be aged ≥20 years, and to charge less money for intercourse. No difference in mean CD4+ count was noted between women with dual seroreactivity (561±106/l), and HIV-1 -seropositive women (588 ± 106/l).
ConclusionsFemale sex workers in Abidjan had the highest absolute (30%), and proportional rate (38%) of dual seroreactivity yet described in any population. Increased sexual exposure is associated with an increased risk of dual seroreactivity. Although better molecular diagnostic techniques are required, a substantial proportion of female sex workers in Abidjan is likely to be infected with both HIV-1, and HIV-2.
© Lippincott-Raven Publishers.