1. State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China; Tel: +86-22-59596242; Fax: +86-22-59596586
2. Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China; Tel: +86-22-59596242; Fax: +86-22-59596586
3. Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China; Tel: +86-22-59596171; Fax: +86-22-27386453
4. Tianjin Zhongxin Pharmaceutical Group Co., Ltd. Le Ren Tang Pharmaceutical Factory, Tianjin, 301617, China
5 Faculty of Pharmacy, Mahasarakham University, Kantharawichai, Maha Sarakham Province, Thailand
Yaxin Qi, Meng Wang, Lijuan Chai contributed equally to this work.
* Corresponding author. Yi Wang, School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China, E-mail: [email protected]; Peng Zhang, School of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China, E-mail: [email protected]; Lin Miao, School of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China, E-mail: [email protected]
Conflicts of interest statement: None.
Funding: This work was supported by the Science and Technology Project of Tianjin (22ZXGBSY00020 and 21ZYJFJC0070), National Key Research and Development Project of China (2021YFC1712904), and the National Natural Science Foundation of China (82074105). It was also supported by the Clinical Enhancement Project of traditional Chinese medicine from National Administration of Traditional Chinese Medicine.
Ethical approval of studies and informed consent: The experimental procedures were approved by the Tianjin University of Traditional Chinese Medicine Animal Research Committee (TCM-LAEC20170018)
Acknowledgments: None.
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