DERMATOLOGY DILEMMASA Case of Multisystem Inflammatory Syndrome in Children Following SARS-CoV-2 Infection in a Rural Emergency DepartmentGlover, Hilary Ashton DNP, FNP-C, ENP-C; Davis, Amy B. MD, FACEPEditor(s): Martinez, Nicole PhD, RN, FNP-BC, ENP-C, PHN, Column Editor Author Information College of Nursing, University of North Alabama, Florence (Dr Glover); and Magnolia Regional Health Center, Corinth, Mississippi (Drs Davis and Glover). Corresponding Author: Hilary Ashton Glover, DNP, FNP-C, ENP-C, College of Nursing, University of North Alabama, Florence, AL 35632 ([email protected]). Disclosure: The authors report no conflicts of interest. Advanced Emergency Nursing Journal: April/June 2021 - Volume 43 - Issue 2 - p 114-122 doi: 10.1097/TME.0000000000000346 Buy CE Test Metrics Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV2), also known as COVID-19, has rapidly spread across the globe resulting in a worldwide pandemic. This disease has such varying presentation within the population. Although rare, multisystem inflammatory syndrome in children (MIS-C) is a potentially fatal complication of SARS-CoV2 infection and can be easily missed in the early stages. Because emergency department (ED) providers are often the initial treating providers, knowledge of the clinical manifestations and treatment of MIS-C is essential. The purpose of this article is to present a case of MIS-C in a rural ED, describe the subtle signs of disease, and educate clinicians on this rare and potentially deadly disease. © 2021 Wolters Kluwer Health, Inc. All rights reserved.