APPLIED PHARMACOLOGYEmergency Department Management of Recent-Onset Atrial FibrillationWeant, Kyle A. PharmD, BCPS, BCCCP, FCCP; Matuskowitz, Andrew J. MD; Gregory, Haili PharmD, BCPS; Caporossi, Jeffrey MD; Hall, Gregory A. MD, MHAEditor(s): Weant, Kyle A. PharmD, BCPS, BCCCP, FCCP, Column Editor Author Information Medical University of South Carolina College of Pharmacy, Charleston (Drs Weant and Gregory); and Department of Emergency Medicine, Medical University of South Carolina, Charleston (Drs Matuskowitz, Caporossi, and Hall). Corresponding Author: Kyle A. Weant, PharmD, BCPS, BCCCP, FCCP, Pharmacy Services, Medical University of South Carolina, 150 Ashley Ave, P.O. Box 250584, Charleston, SC 29425 ([email protected]). Disclosure: The authors report no conflicts of interest. Advanced Emergency Nursing Journal: July/September 2020 - Volume 42 - Issue 3 - p 176-185 doi: 10.1097/TME.0000000000000306 Buy CE Test Metrics Abstract Atrial fibrillation (AF) is the most common tachyarrhythmia managed in the emergency department (ED). Visits to the ED for a presentation of AF have been increasing in recent years, with an admission rate that exceeds 60% in the United States and contributes substantially to health care costs. Recent-onset AF—defined as symptom onset less than 48 hr—is a common ED presentation for which rate control or acute electrical or pharmacological cardioversion may be appropriate treatment modalities depending on patient-specific circumstances. The focus of this review is to discuss the current recommendations regarding the management of recent-onset nonvalvular AF in the ED, discuss medication administration considerations, and identify implementation strategies in the ED to optimize throughput and reduce hospital admissions. © 2020 Wolters Kluwer Health, Inc. All rights reserved.