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Oral Diclofenac Potassium Versus Intravenous Acetaminophen in Acute, Isolated, Closed-Limb Trauma

Momeni, Mehdi, MD; Vahidi, Elnaz, MD; Badrizadeh, Mohsen, MD; Naderpour, Zeinab, MD; Saeedi, Morteza, MD

Advanced Emergency Nursing Journal: January/March 2019 - Volume 41 - Issue 1 - p 48–55
doi: 10.1097/TME.0000000000000224

Pain control is an important concern in limb trauma. The most ideal agent for this purpose varies among different hospitals. The objective of this study was to compare the analgesic effect of oral diclofenac potassium versus intravenous acetaminophen in patients with limb trauma. This was a double-blind randomized clinical trial conducted on 60 adult patients. Oral diclofenac potassium (50 mg) was given in Group D, and intravenous acetaminophen (1 g in 500 ml normal saline over 20 min) was administered in Group A. Patients' pain scores (visual analogue scale) were recorded and compared at baseline, 5, 15, 30, 60 min, and 4 hr after drug administration. The mean age was 42.62 ± 15.42 and 38.04 ± 17.48 years in Group A and Group D, respectively. No significant change was observed between the 2 groups (p = 0.11). In this study, both drugs could decrease the pain score effectively and safely in isolated limb trauma.

Emergency Medicine Research Center, Shariati Hospital (Drs Momeni, Vahidi, and Saeedi), Emergency Medicine Department (Drs Momeni, Vahidi, Badrizadeh, and Saeedi), and Internal Medicine Department (Dr Naderpour), Tehran University of Medical Sciences, Tehran, Iran.

Corresponding Author: Morteza Saeedi, MD, Prehospital Emergency Research Center, Shariati Hospital, Tehran University of Medical Sciences, North Amirabad St, Tehran, Iran (

Authors' contributions: M.M.: study design and supervision; M.B.: data gathering and analysis; E.V.: drafting; Z.N.: data analysis; M.S.: critical revision.

IRCT registration No.: 201703018872N11

Disclosure: The authors report no conflicts of interest.

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