APPLIED PHARMACOLOGYOutpatient Treatment of Uncomplicated Urinary Tract Infections in the Emergency DepartmentSchutz, Douglas PA-C; Watson, Simon C. MD, FACEP; Hayden, Geoffrey MD, FACEP; Weant, Kyle A. PharmD, BCPS, FCCPSection Editor(s): Weant, Kyle A. PharmD, BCPS, FCCP; Column Editor Author Information Department of Emergency Medicine (Mr Schutz and Dr Watson) and Pharmacy Services (Dr Weant), Medical University of South Carolina, Charleston; Charleston Southern University, Charleston, South Carolina (Mr Schutz); and Sidney Kimmel Medical College, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania (Dr Hayden). Corresponding Author: Kyle A. Weant, PharmD, BCPS, FCCP, Pharmacy Services, Medical University of South Carolina, 150 Ashley Ave, PO Box 250584, Charleston, SC 29425 (firstname.lastname@example.org). Disclosure: The authors report no conflicts of interest. Advanced Emergency Nursing Journal: July/September 2018 - Volume 40 - Issue 3 - p 162-170 doi: 10.1097/TME.0000000000000195 Buy Take the CE Test Metrics Abstract One of the most commonly treated infections in the emergency department (ED) is an uncomplicated urinary tract infection. Multiple classes of antibiotics are frequently used to treat this condition, but not all have equivalent efficacy, and many may confer risks to not only the patient but society as a whole if used on a large scale. These antibiotic selections should also be guided by local antimicrobial susceptibility patterns, and general multidisciplinary recommendations for therapy should be developed on a local scale to assist prescribing patterns. The proactive development of a routine approach to reviewing and addressing positive cultures following discharge from the ED should also be developed and implemented in order to ensure that optimal patient care is provided. The objective of this review is to assess the available literature to isolate which antibiotics and approaches to care are the most appropriate options for treating uncomplicated outpatient urinary tract infections in the ED. © 2018 Wolters Kluwer Health, Inc. All rights reserved.