APPLIED PHARMACOLOGYComplements Are Not Always a Good Thing Novel Therapies for AngioedemaBailey, Abby Mynatt PharmD, BCPS; Reed, Brittany S. PharmD; Weant, Kyle A. PharmD, BCPS; Justice, Stephanie Baker PharmD, BCPSSection Editor(s): Weant, Kyle A. PharmD, BCPS; Column Editor Author Information University of Kentucky HealthCare and University of Kentucky College of Pharmacy, Lexington, Kentucky (Dr Bailey); Charleston Area Medical Center, Charleston, West Virginia (Dr Reed); and Medical University of South Carolina, Charleston, South Carolina (Dr Weant); and St. Claire Regional Medical Center, Morehead, Kentucky (Dr Justice). Corresponding Author: Stephanie Baker Justice, PharmD, BCPS, Stephanie Baker Justice, PharmD, BCPS, St. Claire Regional Medical Center, 222 Medical Circle, Morehead, KY 40351 (email@example.com). Disclosure: The authors report no conflicts of interest Advanced Emergency Nursing Journal: April/June 2016 - Volume 38 - Issue 2 - p 93-108 doi: 10.1097/TME.0000000000000097 Buy Metrics Abstract Hereditary angioedema attacks are rare, but emergency care providers must be aware of the clinical presentation and treatment of these patients because the emergency department remains the most common setting where these patients seek treatment. If providers are not aware of the past medical history of these patients, they are likely to receive standard therapies for respiratory distress and anaphylaxis including antihistamines, corticosteroids, and epinephrine. However, these medications may not work in these patients, given the pathophysiology of their underlying disease. Since 2009, several new therapies have been approved for the treatment of acute hereditary angioedema attacks. This article discusses pathophysiology, clinical presentation, and use of novel therapies for the management of angioedema. © 2016 Wolters Kluwer Health, Inc. All rights reserved.