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Adverse Drug Events in the Emergency Department: Why Genetics Matters in Practice

Chismark, Elisabeth PhD, RN; Evans, Dian Dowling PhD, FNP-BC

Section Editor(s): Howard, Patricia Kunz PhD, RN, CEN, CPEN, NE-BC, FAEN; Shapiro, Susan E. PhD, RN

Advanced Emergency Nursing Journal: January/March 2012 - Volume 34 - Issue 1 - p 3–9
doi: 10.1097/TME.0b013e318243027d
Research to Practice

A recent clinical research study with a case study approach is used to illustrate the importance of translational research in the role of the advanced practice nurse. The case study module used in this column is “Adverse Drug Events in the Emergency Department: Why Genetics Matters in Practice.” The study results showed that patients taking multiple drugs metabolized through the cytochrome P450 enzyme system had a higher prevalence of drug–drug exposure. These drug–drug exposures may lead to potentially serious drug–drug interactions. The implications and clinical relevance of these findings for advance practice nurses are discussed.

Clemson University School of Nursing, Clemson, South Carolina (Dr Chismark); and Emory University Nell Hodgson Woodruff School of Nursing, Atlanta, Georgia (Dr Evans).

Corresponding Author: Elisabeth Chismark, PhD, RN, Clemson University School of Nursing, 444 Edwards Hall, Clemson, SC 29634 (

Disclosure: The authors report no conflicts of interest.

© 2012 Lippincott Williams & Wilkins, Inc.