Sialorrhoea is a common adverse effect of a range of medicines, primarily clozapine. At least a third of patients treated with clozapine suffer from sialorrhoea, and the consequences of this can be socially stigmatising and lead to non-adherence. The treatment options are limited and primarily centered around muscarinic antagonism. We suggest non-pharmacological interventions followed by locally applied atropine or glycopyrrolate. If systemic treatment is necessary, amisulpride, benztropine, or terazosin may be attempted.
aClinical Pharmacology and Pharmacy, Department of Public Health, University of Southern Denmark, Odense, Denmark
bDepartment of Clinical Biochemistry and Pharmacology, Odense University Hospital, Odense, Denmark
cPsychiatric Drug Information, Region of Southern Denmark, Vejle, Denmark
dDepartment of Clinical Research, University of Southern Denmark, Odense, Denmark
eHospital Pharmacy, Hospital of South West Denmark, Esbjerg, Denmark
Correspondence to Maija Bruun Haastrup, Clinical Biochemistry and Pharmacology, Odense University Hospital, J B Winsløws Vej 19, 5000 Odense, Denmark. E-mail: email@example.com