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Adverse reactions to intravenous acetylcysteine in paracetamol poisoning

Sandilands, Euan A.; Morrison, Emma E.; Bateman, D. Nicholas

doi: 10.1097/FAD.0000000000000015
Original Article

Summary Intravenous acetylcysteine is used for the management of paracetamol overdose worldwide. Recently, there has been increasing recognition of its adverse effects. This article reviews the features of these reactions, the factors that affect their frequency, and ways to reduce their frequency and severity.

aRoyal Infirmary of Edinburgh

bNPIS Edinburgh

cClinical Pharmacology and Toxicology, QMRI, University of Edinburgh, Edinburgh, UK

Correspondence to Euan A. Sandilands, Royal Infirmary of Edinburgh, Edinburgh, UK. E-mail:

Editor: R E Ferner, MSc, MD, FRCP, Director of the West Midlands Centre for Adverse Drug Reaction Reporting and Consultant Physician at City Hospital, Birmingham, UK. Assistant Editor: Mr C Anton, MA, MEng. Editorial Board: Australia: Dr M Kennedy, Professor G M Shenfield, Denmark: Professor J S Schou; England: Dr J K Aronson; India: Professor N Gogtay; Netherlands: Professor C J van Boxtel, Dr B H Ch Stricker; New Zealand: Dr T Maling; Scotland: Dr D N Bateman; Wales: Professor P A Routledge.

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