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Drug fever

Vodovar, Dominiquea,b; Le Beller, Christinec; Mégarbane, Brunoa,b,d; Lillo-Le Louet, Agnèsc

doi: 10.1097/FAD.0000000000000002
Original Article

Summary Drug-induced fever can occur by a variety of mechanisms: drugs can affect thermoregulation; and they can act directly as a pyrogenic agent, or indirectly by causing the release of an endogenous pyrogenic agent. Diagnosis can be difficult and the consequences of misdiagnosis can be severe.

aDepartment of Medical and Toxicological Critical Care, Lariboisière Hospital

bParis-Diderot University

cRegional Center of Pharmacovigilance, European Georges Pompidou Hospital

dUniversity and INSERM U1144, Paris-Descartes University, Paris, France

Correspondence to Dominique Vodovar, Department of Medical and Toxicological Critical Care, Lariboisière Hospital, Paris, France. Tel: +33 1 49 95 84 42; e-mail:

Editor: R E Ferner, MSc, MD, FRCP, Director of the West Midlands Centre for Adverse Drug Reaction Reporting and Consultant Physician at City Hospital, Birmingham, UK. Assistant Editor: Mr C Anton, MA, MEng. Editorial Board: Australia: Dr M Kennedy, Professor G M Shenfield, Denmark: Professor J S Schou; England: Dr J K Aronson; Ireland: Professor J Feely; Netherlands: Professor C J van Boxtel, Dr B H Ch Stricker; New Zealand: Dr T Maling; Scotland: Dr D N Bateman; Wales: Professor P A Routledge.

© 2014 Lippincott Williams & Wilkins