All anticoagulant treatment increases the risk of bleeding. Warfarin causes foetal abnormalities – chrondrodysplasia punctata, and asplenia – and may increase foetal loss rate; skin necrosis and rarer adverse reactions. Unfractionated heparins can cause osteoporosis, thrombocytopenia with or without thrombosis, and other rare reactions. Low molecular weight heparins are less likely to do so.
Section of Pharmacology, Therapeutics and Toxicology, Cardiff University School of Medicine, Heath Park, Cardiff CF14 4XN
Editor: R E Ferner, MSc, MD, FRCP, Director of the West Midlands Centre for Adverse Drug Reaction Reporting and Consultant Physician at City Hospital, Birmingham, UK. Assistant Editor: Mr C Anton, MA, MEng. Editorial Board: Australia: Dr M Kennedy, Professor G M Shenfield, Denmark: Professor J S Schou; England: Dr J K Aronson; Ireland: Professor J Feely; Netherlands: Professor C J van Boxtel, Dr B H Ch Stricker; New Zealand: Dr T Maling; Scotland: Dr D N Bateman; Wales: Professor P A Routledge.