Many drugs can cause fever, by a variety of mechanisms. Drugs such as interferons can stimulate the production of endogenous pyrogens, and antibacterial agents such as penicillins can kill organisms and so release endotoxins, as in the Jarisch-Herxheimer reaction. Irritant drugs can produce local phlebitis. Alterations of thermoregulation by anticholinergic agents, amphetamines including Ecstasy, and serotoninergic agents are all important causes of drug-induced (ever. Antituberculous agents and anticonvulsants are implicated in fever due to hypersensitivity reactions; and some drugs can cause severe hyperthermia in susceptible individuals, for example anaesthetic agents in patients predisposed to malignant hyperthermia. Drugs should be suspected in any case of fever the cause of which is obscure.
© 1999 Lippincott Williams & Wilkins, Inc.