Original ArticlesModel of Family Caregiver Resilience and Burden in Opioid Use Disorder A Theoretical FrameworkTyo, Mirinda B. PhD, RN, TCRN; McCurry, Mary K. PhD, RNC, ANP, ACNP Author Information University of Massachusetts Dartmouth, Dartmouth. Correspondence: Mirinda B. Tyo, PhD, RN, TCRN, University of Massachusetts Dartmouth, College of Nursing and Health Sciences, 285 Old Westport Rd, Dartmouth, MA 02747 ([email protected]). Mirinda B. Tyo is an Assistant Professor and Mary McCurry is a Professor in the College of Nursing and Health Sciences, University of Massachusetts Dartmouth, Dartmouth, Massachusetts. The authors have disclosed that they have no significant relationships with, or financial interest in, any commercial companies pertaining to this article. Advances in Nursing Science 46(2):p 147-157, April/June 2023. | DOI: 10.1097/ANS.0000000000000448 Buy Metrics Abstract This theory synthesis provides a theoretical model for nursing researchers to examine factors that influence resilience and burden in family caregivers of individuals with opioid use disorder. Two frameworks, the Resiliency Model and the Conceptual Framework for Family Involvement with Adults with Co-occurring Substance and Mental Disorders, were synthesized and modified by incorporating concepts and conceptual relationships from recent research studies and experiential knowledge from clinical practice to develop a new model. The model predicts the impact of caregiver characteristics, caregiver support, stressors, and caregiver-care recipient dyad characteristics on caregiver well-being. © 2022 Wolters Kluwer Health, Inc. All rights reserved.