ArticleThe Knowledge Base for Evidence-based Nursing: A Role for Mixed Methods Research?Flemming, Kate MSc, RNAuthor Information Department of Health Sciences, The University of York, Heslington, UK. Corresponding author: Kate Flemming, MSc, RN, Department of Health Sciences, The University of York, Area 2, Seebohm Rowntree Bldg, University Rd, Heslington, York, YO10 5DD, UK (e-mail: email@example.com). The author is funded by a Research Scientist in Evidence Synthesis Researcher Development Award from the Department of Health and NHS R&D. Thanks to Dr Karl Atkin and Prof Trevor Sheldon, Department of Health Sciences, The University of York, UK, and to Dr Mary Dixon-Woods, Department of Health Sciences, The University of Leicester, UK, for supervision and advice on earlier drafts of this article. Advances in Nursing Science: January-March 2007 - Volume 30 - Issue 1 - p 41-51 Buy Abstract Evidence-based nursing is central to the knowledge base for nursing practice. Critics of evidence-based nursing dislike the central role that randomized controlled trials (RCTs) take in providing evidence for nursing, claiming that the context and experience of nursing care are removed from evaluation. Many nursing decisions involve questions regarding the effectiveness of interventions, best evaluated by RCTs. This article explores the epistemological and practical feasibility of combining qualitative research with RCTs (mixed methods research) in evaluations of nursing practice. Through theoretical and practical examples, it proposes that mixed methods research has the potential to enhance the evidence base for nursing. © 2007 Lippincott Williams & Wilkins, Inc.