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Fungal Prophylaxis in Neonates: A Review Article

Lollis, Tyner R. MSN, RN, NNP-BC; Bradshaw, Wanda T. MSN, RN, NNP-BC, PNP

Section Editor(s): Zukowsky, Ksenia

doi: 10.1097/ANC.0000000000000048
Beyond the Basics

Fungemia is a serious problem within neonatal intensive care units around the world. Premature infants are at high risk for this complication, which is often fatal. Prophylaxis for invasive fungal infection has been practiced worldwide in different settings and with various patient groups. Both oral and intravenous drugs have been used with some success. In the population of preterm infants, oral nystatin, intravenous fluconazole, and intravenous amphotericin B have all been cited as possible drugs for prophylactic use. Intravenous fluconazole has emerged as the best choice for chemoprophylaxis in premature infants.

Duke University School of Nursing, Durham, North Carolina (Mss Lollis and Bradshaw); Novant Health Presbyterian Medical Center, Charlotte, North Carolina (Ms Lollis); and Duke University Health System, Durham, North Carolina (Ms Bradshaw).

Correspondence: Tyner R. Lollis, MSN, RN, NNP-BC, 200 Hawthorne Ln, Charlotte, NC 28204 (

All authors and coauthors of this manuscript have read and approved this manuscript for publication and have all contributed equal substance to this work.

The authors declare no conflict of interest.

© 2014 by The National Association of Neonatal Nurses