Original ArticlesEmerging Challenges in COVID-19 With Substance Use DisordersSalahuddin, Mohammed MSc*; Manzar, Md Dilshad PhD†; Pandi-Perumal, Seithikurippu R. MSc‡; Bahammam, Ahmed S. MD§,∥ Author Information *Department of BioMolecular Sciences, Pharmacology Division, University of Mississippi, Oxford, MS †Department of Nursing, College of Applied Medical Sciences, Majmaah University, Al Majmaah §University Sleep Disorders Center ∥National Plan for Science and Technology, College of Medicine, King Saud University, Riyadh, Saudi Arabia ‡Somnogen Canada Inc., Toronto, ON, Canada The authors declare no conflict of interest. Correspondence to: Mohammed Salahuddin, MSc, Department of BioMolecular Sciences, School of Pharmacy, University of Mississippi, 331 Faser Hall, P.O. Box 1848, University, MS 38677-1848 (e-mail: [email protected]). Addictive Disorders & Their Treatment: December 2021 - Volume 20 - Issue 4 - p 444-453 doi: 10.1097/ADT.0000000000000266 Buy Metrics Abstract Background and Objective: People with substance use disorder (SUD) may be easily vulnerable to coronavirus disease-19 (COVID-19). Given the impaired lung function caused by COVID-19 may exacerbate the symptoms of patients already having preexisting opioids or central nervous system stimulants use disorder. This narrative review highlights the risks of interactions between COVID-19 and SUD. Methods: This article has systematically reviewed and collated relevant papers and articles identified through PubMed focusing on SUD and COVID-19. Results: SUD is characterized by an array of combined mental, physical, and behavioral symptoms, which is undoubtedly of great public health concern especially in the context of the recent advent of the COVID-19 pandemic. The myriad of physiological changes caused by COVID-19 and SUD may be additive or synergistic on various organ functions, hence this review has highlighted potential challenges and possible outcomes because of these interactions. Systematic delineation to parse out the combined COVID-19 and SUD pathology on a given organ function is crucial. Moreover, the primary measures to tackle the COVID-19 pandemic like home confinement and lack of social support may be a significant predictor of relapse in already sober individuals, thus alternate methodologies may be needed to confine this problem. Conclusion: This review highlights the importance of the intertwined epidemics interactions and proposes early measures to recognize the scope of problem at the individual level to prevent future challenges. Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.