Case ReportsLate-onset Cases of Korsakoff Amnestic Syndrome With CNS Comorbidities: Suggestions for Long-term ManagementWestermeyer, Joseph J. MD, MPH, PhD*,†; Soukup, Beverley RN, MA, CNS* Author Information *Minneapolis VA Health Care Center †Department of Psychiatry, University of Minnesota, Minneapolis, MN The Veterans Administration and the University of Minnesota bear no responsibility for these data or their interpretations. The authors declare no conflict of interest. Correspondence to: Joseph J. Westermeyer, MD, MPH, PhD, 1935 Summit Avenue, Saint Paul, MN 55105 (e-mails: [email protected]; [email protected]). Addictive Disorders & Their Treatment: March 2021 - Volume 20 - Issue 1 - p 74-77 doi: 10.1097/ADT.0000000000000221 Buy Metrics Abstract Goal: The goal of this study was to alert clinicians to Korsakoff syndrome associated with comorbid neurological and neuropsychiatric conditions in patients aged 50 years and older. Methods: The study consists of 4 Korsakoff longitudinal case reports (mean age at onset=60.5 y), supplemented by relevant published reports. Findings: The findings include demographic characteristics, comorbid central nervous system conditions, and interventions. Conclusion: In older patients with Korsakoff syndrome and comorbid central nervous system conditions, the optimal functional outcome depends upon a neurophysiological understanding of all comorbidities plus treatment interventions that can alleviate >1 comorbid condition insofar as feasible. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.