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The Association Between DRD2/ANKK1 TaqIA Polymorphism and Impulsivity in Patients With Opioid Dependence Disorder

Enaba, Dalia A., MD*; Abou el Magd, Samir F., MD; El Baz, Heba N., MD; Hegazy, Nesma, MD*

Addictive Disorders & Their Treatment: March 2019 - Volume 18 - Issue 1 - p 44–52
doi: 10.1097/ADT.0000000000000148
Original Articles

Background: Substance abuse is a multifactorial disorder. Scientists have found that an individual’s inherited traits or temperament contributes to the disorder by shaping a personality strongly linked with the risk of substance abuse. DRD2/ANKK1 TaqIA polymorphism is believed to be associated with impulsive behaviors that lead to substance abuse.

Methods: We assessed 80 opioid dependent patients using Diagnostic and Statistical Manual, Fourth Edition (DSM-IV) and the Urgency—lack of Perseverance—lack of premeditation—Sensation seeking (UPPS) Impulsive Behavior Scale. We extracted DNA from the subjects’ whole blood and genotyped it for DRD2 allelic variants.

Results: Genotype analysis showed that 33.8% of the subjects had TaqIA polymorphism versus 66.3% had normal genotype. The mean value of Urgency subscale of the UPPS in patients with normal genotype is (35.8±9.0) versus (40±8.4) in patients with polymorphism.

Conclusions: Patients with TaqIA polymorphism shows statistically significant higher levels of urgency on UPPS than patients with wild genotype.

*Department of Psychiatry, Faculty of Medicine

Department of Psychiatry

Department of Chemical Pathology, Faculty of Medicine, Cairo University, Cairo, Egypt

The author declares no conflict of interest.

Reprints: Dalia A. Enaba, MD, Psychiatry, Cairo University, Building 7540 st. 23 from 9 st. Mokattam, Cairo 11439, Egypt (e-mail:

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