Original ArticlesThe Association Between DRD2/ANKK1 TaqIA Polymorphism and Impulsivity in Patients With Opioid Dependence DisorderEnaba, Dalia A. MD*; Abou el Magd, Samir F. MD†; El Baz, Heba N. MD‡; Hegazy, Nesma MD*Author Information *Department of Psychiatry, Faculty of Medicine †Department of Psychiatry ‡Department of Chemical Pathology, Faculty of Medicine, Cairo University, Cairo, Egypt The author declares no conflict of interest. Reprints: Dalia A. Enaba, MD, Psychiatry, Cairo University, Building 7540 st. 23 from 9 st. Mokattam, Cairo 11439, Egypt (e-mail: [email protected]). Addictive Disorders & Their Treatment: March 2019 - Volume 18 - Issue 1 - p 44-52 doi: 10.1097/ADT.0000000000000148 Buy Metrics Abstract Background: Substance abuse is a multifactorial disorder. Scientists have found that an individual’s inherited traits or temperament contributes to the disorder by shaping a personality strongly linked with the risk of substance abuse. DRD2/ANKK1 TaqIA polymorphism is believed to be associated with impulsive behaviors that lead to substance abuse. Methods: We assessed 80 opioid dependent patients using Diagnostic and Statistical Manual, Fourth Edition (DSM-IV) and the Urgency—lack of Perseverance—lack of premeditation—Sensation seeking (UPPS) Impulsive Behavior Scale. We extracted DNA from the subjects’ whole blood and genotyped it for DRD2 allelic variants. Results: Genotype analysis showed that 33.8% of the subjects had TaqIA polymorphism versus 66.3% had normal genotype. The mean value of Urgency subscale of the UPPS in patients with normal genotype is (35.8±9.0) versus (40±8.4) in patients with polymorphism. Conclusions: Patients with TaqIA polymorphism shows statistically significant higher levels of urgency on UPPS than patients with wild genotype. Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.