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The Effect of Matrix Model on Depression, Anxiety, and Quality of Life in Methamphetamine Users and Their Caregivers

Masaeli, Nasrin, MS; Zarkob, Hajar, MD; Kheirabadi, Gholamreza, MD; Soleimani, Neda, MS; Amini, Mojhgan, MS

Addictive Disorders & Their Treatment: December 2018 - Volume 17 - Issue 4 - p 186–190
doi: 10.1097/ADT.0000000000000136
Original Articles

Subjects: Addiction is a mental disorder that affects all aspects of life, individual health, family, and society. Methamphetamine is the second widely used illegal drug in the world, and Iran has the fifth highest prevalence of methamphetamine abuse. This study was designed to assess the effectiveness of the Matrix Model interventions in improving quality of life, anxiety, and depression.

Methods: This was a semiexperimental study to assess the effects of the Matrix Model interventions on quality of life, anxiety, and depression in individuals with methamphetamine dependence and their caregivers. We used the short form of the WHO quality of life questionnaire (WHOQOL-BREF), the Zung Self-Rating Anxiety Scale, and Beck Depression Inventory for data collection.

Results: In total, 28 methamphetamine-dependent patients (age, 40.18±12.89 y) and 27 caregivers (age, 32.74±6.75 y) were evaluated. There was no significant differences between the patient and the caregiver group in the mean baseline scores for quality of life, depression, or anxiety (P-values, 0.79, 0.63, and 0.88, respectively). The mean scores for depression and anxiety decreased for both groups after intervention (P<0.05), whereas the mean score for quality of life increased (P<0.05).

Conclusions: Matrix Model intervention is effective in improving quality of life and anxiety-depressive symptoms in patients as well as their caregivers.

Behavioral Sciences Research Center, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Supported by a research grant from Vice Chancellor for Research of Isfahan University of Medical Sciences.

The authors declare no conflict of interest.

Reprints: Gholamreza Kheirabadi, MD, Behavioral Sciences Research Center, Khorshid Hospital, Ostandari St., Isfahan 8145831451, Iran (e-mail:

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