Original ArticleTreatment of Dextromethorphan Dependence with NaltrexoneMiller, Shannon C MD, FASAM, CMROAuthor Information From Addiction Services, Veterans Administration Medical Center; and the Department of Psychiatry, Wright State University School of Medicine, Dayton, Ohio. Disclaimer: The views expressed in this article are those of the author and do not necessarily reflect the official policy or position of the Department of Veterans Affairs. Reprints: Shannon C. Miller, MD, FASAM, CMRO, Building 302, Room 107, VA Medical Center, VISN 10, 4100 W. Third St., Dayton, OH 45428 (e-mail: Shannon.Miller2@med.va.gov). Addictive Disorders & Their Treatment: December 2005 - Volume 4 - Issue 4 - p 145-148 doi: 10.1097/01.adt.0000186359.43340.76 Buy Metrics Abstract Dextromethorphan has been described as one of the most abused dissociative drugs of abuse in America, yet many clinicians are unaware of its potential for abuse and addiction. A case is presented herein supporting the syndrome of dextromethorphan dependence (addiction), describing this drug's unique pharmacological profile, summarizing what little is known about its associated use, and providing the first known description in the peer-reviewed medical literature of the use of an established anti-relapse medication to treat this medical disease. © 2005 Lippincott Williams & Wilkins, Inc.