Original ArticleNon A Non B Variants in the Binary Typology of AlcoholicsPrelipceanu, Dan MD, PhD*; Mihailescu, Radu MD, PhD†Author Information From the *Department of Psychiatry, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania; and †Department of Psychiatry, “Titu Maiorescu” University, Bucharest, Romania. Reprints: Dan Prelipceanu, MD, PhD, 10-12 Berceni str., sector 4, Bucharest, Romania (e-mail: email@example.com). Addictive Disorders & Their Treatment: December 2005 - Volume 4 - Issue 4 - p 149-156 doi: 10.1097/01.adt.0000161055.21801.46 Buy Metrics Abstract The authors analyze the possibility of refining the current trend of bio-typology for subjects with alcohol dependency (as promoted by the teams of von Knorring, Goodwin, Cloninger and Babor). We analyzed a sample of 278 patients with alcohol dependency, and we applied the criteria for dichotomous typology: type 1 (A) with onset of alcohol dependency after 20 years of age, with no significant pedigree, and without aggressive behavior, and type 2 (B) with onset before 20 years of age, significant pedigree (at least 1 parent with alcoholism), and aggressive behavior. After applying the criteria, a residual sample of 55 subjects (19.06%) was left that did not satisfy the above criteria. For this residual sample, the authors analyzed a set of variables (biologic, psychologic, medical, and social). The authors proposed 2 typological variants and some possible future directions for research. The non A non B residuum is a heterogeneous typological group, which suggests the homogeneity of the criteria for the first 2 types and, on the other hand, argues about their incomplete character. © 2005 Lippincott Williams & Wilkins, Inc.