Original ArticleDiagnostic Usefulness of Liver Function Tests in Alcohol and Opioid Dependent PatientsJain, Raka PhD, FRSC*; Varghese, Sunny T MBBS†Author Information From the *National Drug Dependence Treatment Centre and the †Department of Psychiatry, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, Pin-110029, India. Reprints: Raka Jain, PhD, Additional Professor, National Drug Dependence Treatment Centre, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, Pin-110029, India (e-mail: [email protected]). Addictive Disorders & Their Treatment: September 2005 - Volume 4 - Issue 3 - p 117-120 doi: 10.1097/01.adt.0000155724.37245.9c Buy Metrics Abstract This study re-evaluated the diagnostic usefulness of conventional liver function tests in clinic population of alcohol and opioid dependent subjects. A total of 934 blood samples of opioid and alcohol dependent patients seeking treatment at National Drug Dependence Treatment Center, All India Institute of Medical Sciences, New Delhi, India were screened for blood serum enzymes of liver function origin during the period of December 2001 and December 2002. Out of the total samples, 507 pertained to opioid dependent subjects and 427 pertained to alcohol dependent subjects. A significant number of opioid dependent patients as well as alcohol dependent patients showed elevated liver enzymes. Greater number of younger opioid dependent patients had elevation of liver enzymes as compared with older patients. These findings suggest that in a primary care setting conventional LFT's are of limited value in assessing opioid addicts as compared with alcohol dependent patients. More sensitive tests should be available to assess the hepatic function in opioid dependent subjects. © 2005 Lippincott Williams & Wilkins, Inc.