To describe the successful use of quetiapine
in a patient with treatment-resistant schizoaffective disorder
and comorbid crack cocaine addiction.
This case report describes a 34-year-old man with a history of schizoaffective disorder
, depression, and cocaine addiction. After numerous suicide attempts, repeated hospitalizations, and treatment with various conventional and atypical antipsychotics over a 10-year period, the patient showed dramatic improvement on a combination of quetiapine
800 mg/d and gabapentin
1200 mg/d. Over a 5-month period, his mood stabilized; he became less paranoid; he was able to cope better with his auditory hallucinations; and he had no cravings for crack cocaine. In addition, the concomitant administration of quetiapine
in this patient caused no adverse events.
The concomitant use of quetiapine
may have beneficial effects in patients with schizo-affective disorder and comorbid cocaine addiction refractory to other medications. Controlled clinical trials are needed to confirm these findings.