Nonpharmacological approaches to the care of persons with dementia differ from pharmacological treatment in that they consider the interaction between the person, caregiver, environment, and system of care in the treatment design. Such interventions generally provide more personalized care for these individuals, addressing their needs, and considering their preferences. Nonpharmacological interventions have been used to enhance cognition, affect, and performance of activities of daily living; to reinforce a positive sense of self; and to reduce agitation/behavior problems and psychotic symptoms. This article presents a framework for implementing such interventions, provides examples from the literature of existing interventions, and argues for increased advocacy to support their research and use.