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F-15 Free Communication/Slide - Creatine: May 30, 2008 1: 00 PM - 2: 45 PM ROOM: 106

An Open Label Clinical Trial Evaluating the Effects of MyoZene™ with Resistance Training on Changes in Body Composition and Muscle Strength.


May 30 1:00 PM - 1:15 PM

Lou, Lidia; Kalman, Douglas; Feldman, Samantha; Krieger, Diane R.

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Medicine & Science in Sports & Exercise: May 2008 - Volume 40 - Issue 5 - p S97-S98
doi: 10.1249/01.mss.0000321874.57207.d9
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PURPOSE: This study explored the efficacy of post workout supplementation with the sports nutrition product MyoZene, a protein-based product with creatine, on enhancing lean body mass and promoting strength gains when used in combination with a standardized resistance training program.

METHODS: Twelve active healthy males, at least 18 years of age, with a minimum of 6 month history of resistance weight training were enrolled into a 4-week open label study of daily supplementation of a protein creatine product in combination with a 6-day split body resistance training program. Body composition was assessed via DXA and strength/endurance via performance of bench press and leg press exercises to exhaustion. Three warm up sets were completed prior to 2 sets of maximum repetitions to failure (sets 4 and 5), using 100% body weight for bench press and 200% body weight for leg press.

RESULTS: Subjects tended to gain fat free mass (+0.97±1.55 kg; p=0.053) while slightly reducing the percent of body fat (-0.63±1.20%; p=0.095). Significant increases were seen in upper body strength/endurance [increased max reps for sets 4 and 5 at 4 weeks (+2.58±2.84 and +3.0±2.09; p=0.009 and <0.001 respectively)] as well as lower body strength/endurance [increased max reps for sets 4 and 5 at 4 weeks (+5.4±4.6 and +8.6±10.2; p= 0.002 and 0.004 respectively)]. The increases in strength from baseline were 24% mid-study and 32% at study end. There was no safety concerns noted.

CONCLUSION: This is the first study with a protein-creatine product to show increases in muscular endurance/strength as high as 32%. Previous studies have found increases in the range of 5 to 15%. Additional research with a control group and longer duration is warranted.

©2008The American College of Sports Medicine