B-41 Free Communication/Slide - Exercise and Cardiovascular Risk Factors Wednesday, May 29, 2019, 3: 15 PM - 5: 15 PM Room: CC-105A
The Differential Effects Of Amount, Intensity, And Mode Of Exercise Training On A Novel Lipoprotein Multimarker Of Insulin Resistance
723 May 29 4:15 PM - 4:30 PM Ross, Leanna M.1 ; Slentz, Cris A.1 ; Shalaurova, Irina2 ; Connelly, Margery A.2 ; Otvos, James D.2 ; Bales, Connie W.1 ; Houmard, Joseph A. FACSM3 ; Kraus, William E. FACSM1
1 Duke University Medical Center, Durham, NC.
2 Laboratory Corporation of America Holdings (LabCorp), Morrisville, NC.
3 East Carolina University, Greenville, NC.
(No relationships reported)
PURPOSE: To examine the effects of amount, intensity, and mode of exercise training on Lipoprotein Insulin Resistance Index (LP-IR; a relatively new spectroscopic multimarker of insulin resistance) across 10 exercise interventions from the STRRIDE studies.
METHODS: A total of 531 men and women with dyslipidemia [STRRIDE I (n=222) and STRRIDE AT/RT (n=142)] or prediabetes [STRRIDE-PD (n=167)] were randomized to either control group or one of 10 exercise interventions, which ranged from doses of 8-22 kcal/kg/week (KKW); intensities of 50-75% V̇O2peak ; and durations of 6-9 months. Two groups included resistance training and one group included dietary intervention (weight loss goal of 7%). Fasting blood samples were obtained at both baseline and 16-24 hr after the final exercise bout. NMR spectroscopy was performed at LabCorp to determine LP-IR score, which is comprised of six lipoprotein subclass and size parameters. LP-IR score ranges from 0 (most insulin sensitive) to 100 (most insulin resistant). Paired t-tests determined post- minus pre-intervention change score significance within groups (p<0.05). Study-specific ANCOVA determined differences between groups.
RESULTS: The inactive control group did not significantly change LP-IR. After training, seven of the 10 exercise groups significantly improved LP-IR, ranging from -4.0 ± 7.6 to -12.5 ± 14.2. The figure displays change scores across all groups. The Aerobic plus Resistance group resulted in significantly greater change than the Resistance only group in STRRIDE AT/RT. The Moderate plus Diet group had significantly greater LP-IR change than all other groups in STRRIDE-PD.
CONCLUSION: On average, STRRIDE interventions improved LP-IR. Our results provide compelling evidence that adding resistance to aerobic training elicits a synergistic training effect on LP-IR. In individuals with prediabetes, incorporating dietary intervention with aerobic training results in the most robust LP-IR improvement.
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