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E-39 Free Communication/Poster - Ergogenic Aids III - Bicarbonate and Caffeine Friday, June 1, 2018, 7: 30 AM - 12: 30 PM Room: CC-Hall B

Double-blind, Placebo Controlled, Randomized Crossover Pilot Study Evaluating The Impacts Of Sodium Bicarbonate in a Transdermal Delivery System on Physiological Parameters and Exercise Performance

2402 Board #238 June 1 11

00 AM - 12

30 PM

Kern, Mark1; Misell, Lisa M.2; Ordille, Andrew1; Alm, Madeline1; Salewske, Brookell1

Author Information
Medicine & Science in Sports & Exercise: May 2018 - Volume 50 - Issue 5S - p 595
doi: 10.1249/01.mss.0000537049.16090.97
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Oral sodium bicarbonate has been used for decades as an ergogenic aid by buffering muscle acid production during exercise and subsequently delaying the onset of fatigue in athletes. However, gastrointestinal side effects limit the use of sodium bicarbonate.

PURPOSE: This study evaluated the efficacy of a commercially available topical transdermal sodium bicarbonate (TSB) lotion (Topical Edge™) which is claimed to be delivered through the skin using a novel patent-pending transdermal delivery system for impacting exercise metabolism and performance.

METHODS: 20 trained cyclists (Category 1-3) and a professional triathlete participated in this randomized, cross-over, double-blinded, placebo-controlled study. After application of TSB or placebo lotions, subjects completed a variety of exercise and performance tests. On one day subjects completed a high-intensity series of exercise tests which included a ramped protocol until reaching a rating of perceived exertion (RPE) of 17 out of 20, a 30-second sprint performance test, and a 5-minute time trial performance test, with 5 minutes of recovery between tests. On a separate day subjects completed a 1-hour time trial. Heart rate, RPE, blood lactate and pH were assessed before, during, and after performance testing.

RESULTS: Heart rate and RPE were significantly (p<0.05) lower for TSB compared to placebo at the 15-min mark of the 1-hour time trial, but not at other time points. When TSB was applied, lactate was higher (p<0.05) after the high-intensity ramp, sprint and 5-min time trial series (10.8±3.2 mmol/L versus 9.7±3.1 mmol/L for TSB and placebo, respectively). Similar effects were not observed after the 1-hour time trial. Significance was not reached when examining performance differences (p>0.05).

CONCLUSIONS: Overall, the findings from this study provide evidence that TSB can significantly impact blood lactate, heart rate and RPE during performance tests of varying intensity/length. These significant findings support the ability of this lotion to trandermally deliver sodium bicarbonate, which could allows athletes to avoid the side- effects of oral bicarbonate use. Further research is warranted to substantiate these findings and determine the most effective use for this commercially available transdermal sodium bicarbonate lotion.

© 2018 American College of Sports Medicine