Journal Logo

EPIDEMIOLOGY

Meta-analysis of Cigarette Smoking and Musculoskeletal Injuries in Military Training

BEDNO, SHERYL A.1; JACKSON, RHONDA2,3; FENG, XIAOSHU2,3; WALTON, IMANI L.4; BOIVIN, MICHAEL R.2; COWAN, DAVID N.2,3

Author Information
Medicine & Science in Sports & Exercise: November 2017 - Volume 49 - Issue 11 - p 2191-2197
doi: 10.1249/MSS.0000000000001349

Abstract

Tobacco use and musculoskeletal injuries are two of the most important public health problems affecting the US military. Tobacco use is the single largest preventable cause of disease and premature death in the United States and use is higher among military service members compared with their civilian counterparts (8). Approximately 32% of active duty service members report using tobacco (women, 15%; men, 34.5%) (39). Tobacco use is associated with a myriad of health problems, including heart disease, pulmonary disease, many types of cancer, adverse reproductive outcomes, and worsening of other preexisting health conditions. In the context of musculoskeletal injuries, cigarette smoking has been associated with tissue hypoxia, decrease in wound healing, impairment of blood flow, and a higher rate of postoperative healing complications (18,26,27,33).

Injuries have historically been the leading cause of morbidity among US service members (19). Lower-extremity overuse injuries are particularly burdensome to military service members and have been among the top injuries leading to limited duty days (32). Overuse injuries are common and have been most frequently studied in the basic combat training (BCT) environment (11). Overuse injuries are those injuries associated with running, overtraining, overexertion, repetitive movements and activities, vibratory forces, and prolonged static positioning (14). Lower-extremity overuse injuries may account for up to 75% of injuries among men and 78% among women in BCT (25). Women have about twice the risk of musculoskeletal injury compared with men (5,23).

A number of published studies have explored the relationship between cigarette smoking and the risk of overuse injuries, especially among military populations. However, to our knowledge, no summary of the findings of individual research publications has been conducted. Some studies have reported significant associations (1,20,23), whereas others have not noted such a relationship (34,38). Evaluation of the literature is complicated by the fact that different measures of exposure and endpoint have been used, and different demographic and lifestyle variables simultaneously evaluated. Although Bulzacchelli et al. (7) published a review of risk factors for injury among soldiers in BCT, the review was limited to the first 70 d of military service. The authors concluded that there was “strong evidence of increased risk” among men, but only “mixed” evidence among women. The article provided no overall quantification of the level of increased risk associated with smoking for men or women (7).

Although each soldier is evaluated for tobacco use during their primary care and most specialty medical appointments, there are no specific recommendations against cigarette smoking or tobacco use regarding the potential effects on training related injuries. The purpose of this study was to conduct a structured review of the published literature on the impact of cigarette smoking on the risk of lower-extremity overuse injuries in military training (from this point referred to as “training injuries”). Because injury risk is much higher among military women, whereas the prevalence of smoking is higher among men, analyses were stratified by sex.

METHODS

Search criteria

A literature search was conducted of the Cumulative Index of Nursing and Allied Health Literature (CINAHL), Public/Publisher MEDLINE (PUBMED), and Psychological Information Database (PSYCHInfo) databases using terms listed below. A variety of search terms were explored; some returned an unusable number of hits. The final search terms used were:

  • (musculoskeletal injuries OR overuse injuries OR lower-extremity injury OR stress fractures OR hip fractures OR muscle strain OR knee pain)
  • AND
  • (cigarette smoking OR tobacco OR smoking OR cigarettes)
  • AND
  • (military OR Army OR Navy OR Soldier OR Marines)
  • NOT
  • (smokeless tobacco OR motor vehicle accidents OR risk taking behavior OR burns OR addiction OR cessation OR withdrawal OR memory loss OR carpal tunnel OR osteoporosis).

Limits applied were English language publications, age groups (adults ages 19–44 yr, the age group with data available that is closest to the recruit population, generally 18 to 35 yr). Review articles were excluded. The dates of publication were January 1980 through October 2016. We also searched Google Scholar and references of the articles to ensure any other relevant literature was captured, that potentially met our criteria.

Data abstraction

We performed an initial screening of abstracts, and those that did not meet the inclusion criteria were eliminated based on the abstract alone. The remaining articles were reviewed using a hybrid form that included the article abstract, and also classified the article (see document, Supplemental Digital Content 1, Hybrid form, http://links.lww.com/MSS/A968). Data were entered into the hybrid form, and reviewed by at least one other person before an article was removed from consideration. After a review of all of the hybrid forms, more articles were eliminated as not being relevant.

Article quality evaluation

Two of us (S.A.B. and D.N.C.) used a data abstraction tool (available upon request), modified from a tool used in Bullock et al. (6). Each reviewer evaluated a series of characteristics and assigned a quality (objective) score. Characteristics reviewed include the research question, source of subjects (inclusion, exclusion criteria), measurement of exposures/risk factors, study design, data on confounders and covariates, statistical methods, whether incidence rates, risks, or odds were used appropriately, use of confidence intervals or P values, multivariable methods, and inclusion of risks or rates for relevant confounders or demographics, with scores from 0 to 14 possible. Each of us (S.A.B. and D.N.C.) also assigned a Subjective Overall Article Quality score based on the overall impression of each article. Each article was rated as 0, unacceptable; 1, acceptable; 2, good to excellent.

Specific threshold scores were not established. Instead, the reviewers evaluated the articles based on subjective and objective criteria. After all the articles were reviewed and the data abstracted to a spreadsheet, the scoring by S.A.B. and D.N.C. were compared. If there were differences in opinion in the suitability score (if only one author scored the article as unacceptable), the authors further discussed the article and negotiated agreement. Forest plots were generated using R (R Core Development Team, Version 3.1.2) with both the point estimate and 95% confidence interval presented. Plots were generated for smoking yes/no, and for levels of smoking compared with no smoking, overall and stratified by sex.

Meta-analysis of smoking/no-smoking groups

Individual study data that met criteria were pooled using meta-analytical techniques. Meta-analyses involving response outcomes were based on hazard or risk rate ratios (RR) for smoking compared with nonsmoking. If only the odds ratios were reported, where possible the RR was calculated from the data presented in the article (12). The results of individual studies were pooled using both random-effect and fixed-effect models, and weighted RR with the corresponding 95% confidence limits (CL) generated and reported as RR with 95% lower limit, upper limit. The meta-analytical technique is used to combine the risk or hazard ratios, where the ratio, standard error, and sample size for each group are known. The weight given to each study was determined by the inverse of the variance of its estimate of effect. All statistical analyses were carried out using R “meta” package.

Meta-analysis of dose–response

Because different measures of smoking intensity were reported (e.g., packs per day, number per day), a nonparametric approach to assessing dose–response was used, with levels characterized as none, low, medium, high, and highest. The referent group for each data point was nonsmokers, and a rank-order was assigned to each of the levels of smoking (lowest, medium, highest) as described in each article. The results are interpreted as the RR for injury given the level of smoking, compared with the no-smoking group, and as a measure of dose–response. Tests of heterogeneity were conducted overall and separately for men and women.

RESULTS

The search yielded 129 initial studies and 87 were excluded based on title alone (Fig. 1). Forty-two studies underwent quality review, and we excluded 28 based on established criteria. We considered six additional articles after 2013. Two were rated as good to excellent and retained. We included 18 studies in our final analysis (Table 1).

FIGURE 1
FIGURE 1:
Flowchart of screened and included studies.
TABLE 1
TABLE 1:
Study citations and description.

Of the 26 measures of smoking as yes/no reported from 18 studies evaluated (Fig. 2), the RR for injury associated with smoking ranged from 0.74 to 3.10, with a median value of 1.33. Twenty-four (92%) had a point estimate greater than 1.00 (regardless of significance), and 19 (73%) had a lower CL greater than 1.00. Most of the data points (14) were based on men, 11 were based on women, and one combined men and women.

FIGURE 2
FIGURE 2:
Smoking and musculoskeletal injury in military training. CI, confidence intervals; HR, hazard ratio; N: number of subject; *1, any MSI; 2, stress fracture; 3, overuse injury; 4, time loss injury; 5, any index injury (installation index injury [III], modified installation index injury [MIII], training injury index [TII], comprehensive injury index [CII], overuse injury index [OII]); 6, self-reported injury; 7, medical records injury; 8, women; 9, men.

Overall and for each sex, there was some degree of heterogeneity, with I2 of 47% overall, 56.7% for men, and, 16.2% for women. Based on the Cochrane Handbook guidelines (17), the I2 for men could represent moderate to substantial heterogeneity, whereas overall, and for women, it could represent moderate heterogeneity.

There were no substantive differences between the fixed effects and random effects models and only fixed effects results are presented. The weighted average RR between smoking (yes/no) and injury across all data points was 1.31 (1.26–1.36), with a fixed effects model. For both men and women, smoking was significantly associated with injury, with RR of 1.31 (1.26–1.36) and 1.23 (1.11–1.36), respectively.

Nine studies provided 14 data points for levels of smoking, nine for men, and five for women. When the level of smoking was considered (Fig. 3 and Table 2), overall and for men and women, each level had a RR significantly greater than 1.0, compared with nonsmokers. There was a significant linear overall trend between level of smoking (dose) and injury (response) (Cochran–Armitage trend test Z = 16.8462, P < 0.001). The increase in risk for the lowest level of smoking was 43% for women and 26% for men; the increase for the highest level was 56% for women and 84% for men.

FIGURE 3
FIGURE 3:
Smoking levels and musculoskeletal injury in military training for men and women.
TABLE 2
TABLE 2:
Association between levels of smoking and musculoskeletal injuries in military training relative to nonsmokers.

DISCUSSION

The implication for persons entering the military, and most likely, persons beginning any new strenuous activity is that smoking is a preventable risk factor for overuse musculoskeletal injury. Although prevalence of smoking has decreased overall, smoking remains higher among active duty service members (35% among active duty men younger than 25 yr, the age of most accessions) (39) compared with 19% of civilians (3) and is a modifiable risk factor for a range of medical conditions among military personnel, including not just musculoskeletal injury, but also mental health disorders (13).

This review provides a wider scope than the report by Buzacchelli et al. 2014 (8) in that it is not restricted to the first 70 d of military service, a quantified estimate of effect separately for both men and women, and includes a measure of intensity of smoking. This review indicates that smoking is a consistent moderate risk factor for overuse injury among military personnel of both sexes during training.

When considered as a dichotomous variable, the additional risk associated with smoking is about 37% over nonsmokers. A dose–response was apparent as risk of injury increased with increasing smoking intensity, every level above baseline had a RR statistically significant greater than 1.0. At the highest levels, among men, this risk is 1.87 times baseline, and among women, the risk is 1.56 times baseline. The biologically plausible significant dose–response increases our confidence that the findings are valid.

The strengths of this review include that many studies of smoking and injury have been conducted among military populations during training, providing a solid base of knowledge. Military training populations are unique in that trainees are very heterogeneous in terms of sex, age, race, fitness, and other characteristics, while their exposures in training are very similar. Demographic characteristics and medical encounters are well measured.

The weaknesses of this review include: that not all smoking exposures and endpoints were measured the same, and not all studies controlled for factors that could be important confounders (e.g., fitness, body mass index, heavy alcohol use). However, the consistency and significance of the weighted analysis strengthen the argument that smokers are at increased risk of musculoskeletal injury. This association is found among both men and women, and there is also a dose–response between level of smoking and risk of injury.

Because both smoking and musculoskeletal injuries are so prevalent, smoking adds a substantial public health burden, impacting not just the individuals, but also military health care and military training systems. All military branches have tobacco control and use policies, and initial entry military trainees are banned from using tobacco. Given the close supervision exercised over basic trainees, there is little doubt that both the proportion of individuals and the intensity of smoking is substantially reduced from before military entrance. However, it is acknowledged that this ban is not 100% effective. Because trainees continue to be at increased injury after presumably quitting, it is likely that smoking produces a medium- to long-term effect on bone and muscle physiology (29,35).

Future studies on tobacco use and musculoskeletal injuries in military training should include specific questions on past and current smoking, including different types and quantities of tobacco use (i.e., smokeless tobacco and e-cigarettes). Tobacco use documentation in electronic health encounters should be comprehensive and searchable so that future studies can better evaluate associations between tobacco use and injuries. These studies should also include questions related to potential confounders of tobacco use, including alcohol use.

There is no funding declared. The authors would like to thank Ms. Janice Gary, BS, Preventive Medicine Branch, Walter Reed Army Institute of Research, ManTech International Corporation, Health and Life Sciences, for her administrative support of this manuscript.

The results of the study are presented clearly, honestly, and without fabrication, falsification, or inappropriate data manipulation and do not constitute endorsement by ACSM.

Conflict of interest: Material has been reviewed by the Walter Reed Army Institute of Research and Womack Army Medical Center. There is no objection to its presentation and/or publication. The opinions or assertions contained herein are the private views of the authors, and are not to be construed as official, or as reflecting true views of the Department of Defense, Department of Army, US Army Medical Department or the US Government.

REFERENCES

1. Altarac M, Gardner JW, Popovich RM, Potter R, Knapik JJ, Jones BH. Cigarette smoking and exercise-related injuries among young men and women. Am J Prev Med. 2000;18(3 Suppl):96–102.
2. Anderson MK, Grier T, Canham-Chervak M, Bushman TT, Jones BH. Occupation and other risk factors for injury among enlisted US Army Soldiers. Public Health. 2015;129(5):531–8.
3. Barlas FM, Higgins WB, Pflieger JC, Diecker K. 2011 Health related behaviors survey of active duty military personnel. Fairfax (VA): Department of Defense, DTIC Technical Report No. (ADA582287); [2016 Oct 11]. Available from: http://www.dtic.mil/get-tr-doc/pdf?AD=ADA582287.
4. Bedno SA, Cowan DN, Urban N, Niebuhr DW. Effect of pre-accession physical fitness on training injuries among US Army recruits. Work. 2013;44:509–15.
5. Bell NS, Mangione TW, Hemenway D, Amoroso PJ, Jones BH. High injury rates among female army trainees: a function of gender? Am J Prev Med. 2000;18(3 Suppl):141–6.
6. Bullock SH, Jones BH, Gilchrist J, Marshall SW. Prevention of physical training-related injuries recommendations for the military and other active populations based on expedited systematic reviews. Am J Prev Med. 2010;38(1 Suppl):S156–81.
7. Bulzacchelli MT, Sulsky SI, Rodriguez-Monguio R, Karlsson LH, Hill MO. Injury during U.S. Army basic combat training: a systematic review of risk factor studies. Am J Prev Med. 2014;47(6):813–22.
8. Centers for Disease Control and Prevention. Burden of Tobacco Use in the US; [2016 Oct 11]. Available from: http://www.cdc.gov/tobacco/campaign/tips/resources/data/cigarette-smoking-in-united-states.html.
9. Cowan DN, Bedno SA, Urban N, Yi B, Niebuhr DW. Musculoskeletal injuries among overweight army trainees: incidence and health care utilization. Occup Med (Lond). 2011;61:247–52.
10. Cowan DN, Bedno SA, Urban N, Lee DS, Niebuhr DW. Step test performance and risk of stress fractures among female army trainees. Am J Prev Med. 2012;42:620–4.
11. Department of the Army. Technical Bulletin Medical 592. Washington (DC): Prevention and Control of Musculoskeletal Injuries Associated with Physical Training; [2016 Oct 11]. Available from: http://www.usariem.army.mil/assets/docs/publications/guidance/tbmed592_musculoskeletal_injuries.pdf.
12. Grant RL. Converting an odds ratio to a range of plausible relative risks for better communication of research findings. BMJ. 2014;348:f7450.
13. Gubata ME, Urban N, Cowan DN, Niebuhr DW. A prospective study of physical fitness, obesity, and the subsequent risk of mental disorders among healthy young adults in army training. J Psychosom Res. 2013;75(1):43–8.
14. Hauret KG, Jones BH, Bullock SH, Canham-Chervak M, Canada S. Musculoskeletal injuries description of an under-recognized injury problem among military personnel. Am J Prev Med. 2010;38(1):S61–70.
15. Heir T, Eide G. Injury proneness in infantry conscripts undergoing a physical training programme: smokeless tobacco use, higher age, and low levels of physical fitness are risk factors. Scand J Med Sci Sports. 1997;7:304–11.
16. Henderson NE, Knapik JJ, Shaffer SW, McKenzie TH, Schneider GM. Injuries and injury risk factors among men and women in U.S. Army Combat Medic Advanced individual training. Mil Med. 2000;165:647–52.
17. Higgins JPT, Green S, editors. Cochrane Handbook for Systematic Reviews of Interventions. Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. [2017 10 Apr]. Available from www.handbook.cochrane.org.
18. Jensen JA, Goodson WH, Hopf HW, Hunt TK. Cigarette smoking decreases tissue oxygen. Arch Surg. 1991;126(9):1131–4.
19. Jones BH, Canham-Chervak M, Sleet DA. An evidence-based public health approach to injury priorities and prevention recommendations for the U.S. Military. Am J Prev Med. 2010;38(1 Suppl):S1–10.
20. Jones BH, Cowan DN, Tomlinson JP, Robinson JR, Polly DW, Frykman PN. Epidemiology of injuries associated with physical training among young men in the army. Med Sci Sports Exerc. 1993;25:197–203.
21. Knapik JJ, Brosch LC, Venuto M, et al. Effect on injuries of assigning shoes based on foot shape in air force basic training. Am J Prev Med. 2010;38:S197–211.
22. Knapik JJ, Graham B, Cobbs J, Thompson D, Steelman R, Jones BH. A prospective investigation of injury incidence and injury risk factors among Army recruits in military police training. BMC Musculoskelet Disord. 2013;14:32.
23. Knapik JJ, Sharp MA, Canham-Chervak M, Hauret K, Patton JF, Jones BH. Risk factors for training-related injuries among men and women in basic combat training. Med Sci Sports Exerc. 2001;33(6):946–54.
24. Knapik JJ, Swedler DI, Grier TL, et al. Injury reduction effectiveness of selecting running shoes based on plantar shape. J Strength Cond Res. 2009;23:685–97.
25. Knapik JJ, Cuthie J, Canham-Chervak M, et al. US Army Center of Health Promotion and Preventive Medicine (USACHPPM). Aberdeen Proving Ground (MD), and Fort Jackson (SC): Injury Incidence, Injury Risk Factors, and Physical Fitness of U.S. Army Basic Trainees at Ft. Jackson, South Carolina, Epidemiological Consultation Report No. 29-HE-7513-98; [2016 Oct 11]. Available from: http://www.dtic.mil/dtic/tr/fulltext/u2/a359125.pdf.
26. Lee JJ, Patel R, Biermann JS, Dougherty PJ. The musculoskeletal effects of cigarette smoking. J Bone Joint Surg Am. 2013;95(9):850–9.
27. Mosely LH, Finseth F. Cigarette smoking: impairment of digital blood flow and wound healing in the hand. Hand. 1977;9(2):97–101.
28. Munnoch K, Bridger RS. Smoking and injury in Royal Marines’ training. Occup Med (Lond). 2007;57:214–6.
29. Petersen AM, Magkos F, Atherton P, et al. Smoking impairs muscle protein synthesis and increases the expression of myostatin and MAFbx in muscle. Am J Physiol Endocrinol Metab. 2007;293(3):E843–8.
30. Reynolds KL, Heckel HA, Witt CE, et al. Cigarette smoking, physical fitness, and injuries in infantry soldiers. Am J Prev Med. 1994;10:145–50.
31. Ross J, Woodward A. Risk factors for injury during basic military training. Is there a social element to injury pathogenesis? J Occup Med. 1994;36:1120–6.
32. Ruscio BA, Jones BH, Bullock SH, et al. A process to identify military injury prevention priorities based on injury type and limited duty days. Am J Prev Med. 2010;38:S19–33.
33. Scolaro JA, Schenker ML, Yannascoli S, Baldwin K, Mehta S, Ahn J. Cigarette smoking increases complications following fracture: a systematic review. J Bone Joint Surg Am. 2014;96(8):674–81.
34. Shaffer RA, Brodine SK, Almeida SA, Williams KM, Ronaghy S. Use of simple measures of physical activity to predict stress fractures in young men undergoing a rigorous physical training program. Am J Epidemiol. 1999;149(3):236–42.
35. Sorensen LT, Jorgensen S, Petersen LJ, et al. Acute effects of nicotine and smoking on blood flow, tissue oxygen, and aerobe metabolism of the skin and subcutis. J Surg Res. 2009;152(2):224–30.
36. Taanila H, Suni JH, Kannus P, et al. Risk factors of acute and overuse musculoskeletal injuries among young conscripts: a population-based cohort study. BMC Musculoskelet Disord. 2015;16:104.
37. Taanila H, Suni J, Pihlajamäki H, et al. Aetiology and risk factors of musculoskeletal disorders in physically active conscripts: a follow-up study in the Finnish Defence Forces. BMC Musculoskelet Disord. 2010;11:146.
38. Trone DW, Cipriani DJ, Raman R, Wingard DL, Shaffer RA, Macera CA. Self-reported smoking and musculoskeletal overuse injury among male and female U.S. Marine Corps recruits. Mil Med. 2014;179(7):735–43.
39. US Army Public Health Center. Aberdeen Proving Ground (MD): Health of the Force: Create a healthier force for tomorrow; [2016 Oct 11]. Available from: https://phc.amedd.army.mil/PHC%20Resource%20Library/HOF.pdf.
Keywords:

TOBACCO; MUSCULOSKELETAL; EPIDEMIOLOGY; POLICY

Supplemental Digital Content

© 2017 American College of Sports Medicine