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Exercise following Mental Work Prevented Overeating

NEUMEIER, WILLIAM H.; GOODNER, EMILY; BIASINI, FRED; DHURANDHAR, EMILY J.; MENEAR, KRISTI S.; TURAN, BULENT; HUNTER, GARY R.

Medicine & Science in Sports & Exercise: September 2016 - Volume 48 - Issue 9 - p 1803–1809
doi: 10.1249/MSS.0000000000000961
APPLIED SCIENCES

Mental work may promote caloric intake, whereas exercise may offset positive energy balance by decreasing energy intake and increasing energy expenditure.

Purpose This study aimed to replicate previous findings that mental work increases caloric intake compared with a rest condition and assess whether exercise after mental work can offset this effect.

Methods Thirty-eight male and female university students were randomly assigned to mental work + rest (MW + R) or mental work + exercise (MW + E). Participants also completed a baseline rest (BR) visit consisting of no mental work or exercise. Visit order was counterbalanced. During the MW + R or MW + E visit, participants completed a 20-min mental task and either a 15-min rest (MW + R) or a 15-min interval exercise (MW + E). Each visit ended with an ad libitum pizza lunch. A two-way repeated-measures ANOVA was used to compare eating behavior between groups.

Results Participants in the MW + R condition consumed an average of 100 more kilocalories compared with BR (633.3 ± 72.9 and 533.9 ± 67.7, respectively, P = 0.02), and participants in MW + E consumed an average of 25 kcal less compared with BR (432.3 ± 69.2 and 456.5 ± 64.2, respectively, P > 0.05). When including the estimated energy expenditure of exercise in the MW + E conditions, participants were in negative energy balance by an average of 98.5 ± 41.5 kcal, resulting in a significant difference in energy balance between the two groups (P = 0.001).

Conclusion An acute bout of interval exercise after mental work resulted in significantly decreased food consumption compared with a nonexercise condition. These results suggest that an acute bout of exercise may be used to offset positive energy balance induced by mental tasks.

1Department of Psychology, University of Alabama at Birmingham, Birmingham, AL; 2Department of Human Studies, University of Alabama at Birmingham, Birmingham, AL; and 3Department of Kinesiology and Sports Management, Texas Tech University, Lubbock, TX

Address for correspondence: William H. Neumeier, Ph.D., UAB Lakeshore Foundation Research Collaborative, SHPB 341, 1720 2nd Ave S, Birmingham, AL 35294-1212; E-mail: whneumei@uab.edu.

Submitted for publication December 2015.

Accepted for publication March 2016.

Sustained mental work may lead to mental fatigue and overeating (5,6). Thus, a sedentary lifestyle accompanied by increased mental work may contribute to positive energy balance and to recent rises in obesity rates (2,5,6,8,10,36). Exercise contributes to negative energy balance and may affect appetite, thereby altering the effect of mental work on energy balance.

Chaput and Tremblay (7) observed a 200-kcal increase in food consumption after a 45-min reading task compared with a rest condition, despite actual energy expenditure differing by only 3 kcal in the two conditions. Similar increases in food intake were observed after reading tasks (approximately 200 kcal increase) and computerized tests (approximately 250 kcal increase) in comparison with a rest condition (5). Also, a high workload before the grant deadlines of the National Institutes of Health has been associated with increased energy intake compared with low workload conditions (25). Another study has suggested an increase in carbohydrate intake after a mental stress task, although protein and total energy intake did not significantly differ between stress and nonstress conditions (14). Mentally demanding tasks may affect the brain’s energy demands (14) and thus localize brain glucose/glycogen availability. This may contribute to feelings of fatigue and hunger, thereby increasing the chance of consuming more calories than one expends, resulting in a positive energy balance and weight gain (6).

Exercise may serve as a way to provide additional energy for brain function in the form of glucose and lactate (3,32) and decrease calorie intake after mental work. Exercise sessions lasting an hour or less are associated with decreased desire for food and decreased calorie intake (4,9,12,19,27,35,37). A moderate bout of exercise (in the first 15–20 min) increases blood glucose by 10% to 15% and is also associated with higher glucose tolerance (20,39,40). The additional blood lactate provided by exercise may cross the blood–brain barrier (3,32) and offset the brain’s need or desire for food consumption after a mental task.

By receiving additional fuel in the form of glucose and lactate via exercise, the brain may be less likely to signal for increased energy via food consumption. This outlined chain of events supports the glucostatic theory of appetite, where glucose influences hunger and satiety signals to the hypothalamus, thereby influencing short-term appetite control (24). Previous studies have investigated exercise or mental work’s effect on energy intake, but few studies have combined mental work with exercise. One study measured caloric intake after rest, mental work, and exercise and observed increased relative intake after mental work for women and decreased relative intake after exercise for men and women (28). Oh and Taylor (26) observed a 50% decrease in ad libitum chocolate consumption when exercise preceded mental work. In a sample of children, Horsch et al. (16) reported decreased intake of food when physical activity preceded a cognitive stressor. Lemay et al. reported a difference in energy balance after mental work without exercise compared with mental work plus exercise, but did not observe a difference in energy consumption (21). The goal of this study is to replicate increased food consumption after a mental work task, as well as assess exercise’s effect on eating behavior after mental work. This study is novel due to a more controlled and higher-intensity exercise session that immediately precedes an ad libitum meal. The timing of exercise may also affect energy consumption, as exercise immediately preceding a meal has been exhibited to have a stronger anorexigenic effect than when after a meal (1). Timing effects may be of importance, as exercise after a mentally stressful task may be a more natural behavior.

Overall, previous findings support the construct of increased mental workload leading to increased calorie intake and exercise potentially counteracting this effect. This article compares calorie consumption between a mental work scenario, which has been demonstrated to increase calorie intake and a mental work plus exercise scenario, which may result in reduced calorie intake. It is hypothesized that participants in the mental work + exercise (MW + E) group will consume less calories than participants in the mental work + rest (MW + R) group. Exploratory analyses for blood glucose and lactate’s association with eating behavior were also conducted.

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METHODS

Participants were recruited from the university’s undergraduate population. Exclusion criteria were poor health or not able to participate in high effort exercise, preexisting cardiovascular or orthopedic issues, diabetes mellitus, women who were pregnant, taking medications known to affect eating behavior or energy expenditure or insulin sensitivity, food allergies, and body mass index (BMI) greater than 35 kg·m−2. Participants were blinded to the main hypothesis until after they had completed all phases of the study. The study was approved by the university’s institutional review board, and informed consent was obtained from all participants.

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Procedure

All study visits occurred at the university’s Nutrition Sciences Department facilities within a private room or exercise testing laboratory. All participants completed a screening visit, baseline rest (BR) visit, and either MW + R or MW + E visit. After the screening visit, participants were randomly assigned to the MW + R or MW + E protocols, and the order of the BR visit with MW + R or MW + E was counterbalanced. Randomization and counterbalancing were conducted by block randomization with matched pairs and computer generated random numbers. Participants were asked to fast from everything but water for at least 2 h before arrival, to maintain consistent behaviors (sleep, exercise, meals, etc.) before each visit, and to wear exercise clothing to each visit.

At the screening visit, participants’ height, weight, waist circumference, body fat percentage via skinfolds, and V˙O2submax were measured. Participants were also asked preferred pizza toppings from the options available (cheese only, pepperoni, mushroom, black olives, or a combination of toppings). Female participants were asked about timing of their menstrual cycle, and future scheduling avoided the luteal phase.

The BR protocol consisted of a 35-min rest period then self-report satiety and fatigue scales, followed by an ad libitum pizza lunch. During the rest period, the participant was asked to not engage in any mentally or physically stimulating activities (e.g., stretching, reading, conversation, etc.). The MW + R protocol began with a 20-min mental task (described below), then a 15-min rest period, self-report satiety, and fatigue scales and concluded with the ad libitum pizza lunch. The MW + E protocol was similar to the MW + R protocol except a 15-min interval exercise bout took the place of the 15-min rest period. Also, three micro–blood draws from the finger were obtained throughout the visit. Samples were collected at three time points: shortly after arrival to the laboratory (time 1), after the mental work task (time 2), and approximately 4 min after completion of exercise (time 3). The BR and MW + R or MW + E visit occurred approximately 1 wk apart.

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Measures

Anthropometrics

All anthropometric measures (height, weight, waist circumference, and skinfold calipers) were conducted by the same research assistant according to guidelines detailed in the Anthropometric Standardization Reference Manual (22). Height and weight were measured with a scale and stadiometer. Participants emptied their pockets and removed their shoes before measurement. BMI was calculated as BMI = weight / height2 with measured height and weight. For waist circumference and skinfold calipers, participants removed interfering clothing. All measurements were taken on the right side of the body (when applicable). Percent body fat estimation via skinfolds was measured at three sites: triceps, suprailiac, and thigh for females; chest, abdomen, and thigh for males.

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Submaximal V˙O2 assessment

V˙O2submax was measured by indirect calorimetry on a treadmill using a modified Bruce protocol (13). Heart rate monitoring was performed with a POLAR Vantage XL heart rate monitor (Gay Mills, WI, USA). Each assessment was terminated when a participant achieved 80% of age-predicted maximum heart rate, calculated as participant’s age subtracted from 220 then multiplied by 0.8. Participants walked for 4 min at a speed of 3 mph. After the 4 min, grade was increased to 2.5% for another 4 min. Next, grade was increased by 2.5% each minute up to 10% grade, then to 12% for the final grade increase. If a participant had not reached the target heart rate, speed was increased by 0.5 mph·min−1 until termination criteria was achieved. Volumes of O2 and CO2 were measured continuously by open-circuit spirometry and analyzed using an AEI Technologies MAX-II metabolic cart (AEI Technologies, Inc., Pittsburgh, PA). Measurements recorded are averages from each 20 s interval.

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Mental work task

The mental work task for the MW + R and MW + E visit was a sample of graduate entrance examination level reading comprehension problems and one college entrance level math problem. Participants were instructed to try their best and then given 20 min to complete as much of the problem set as possible. Participants answered multiple choice and open ended questions.

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Exercise protocol

The exercise protocol consisted of four 2-min and 24-s work intervals interspersed with three 1-min and 4-s complete rest periods, totaling a 15-min high-intensity interval exercise period. Participants exercised at approximately 80% to 85% of estimated V˙O2 max during the work intervals. The determination of work level was derived from submaximal testing conducted at screening and measured by heart rate. This high-intensity interval protocol was chosen to allow for higher workload in a shorter period and to promote circulating blood glucose and lactate (34). The workload duration and the exercise duration were based on previous research and pilot testing with participants enrolled in the study described here.

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Blood glucose and lactate

Blood samples were collected by finger prick on the nondominant hand using sterile procedures. The first drop of blood after puncture was wiped away, and sensors were applied to succeeding droplets. Glucose sampling always occurred before lactate, and a new droplet was allowed to form between samples. Glucose sampling was conducted with a One Touch Ultra 2 Blood Glucose Monitoring System (LifeScan, Inc., Milspitas, CA) and lactate sampling was conducted with a Lactate Scout+ (SensLab, EKF Diagnostics Company, Barleben, Germany). The measurement after exercise occurred 4 min after completion of the exercise task.

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Eating behavior

Participants were fed premade pizzas purchased from a national retail establishment. Participants were served identically topped pizzas at each feeding visit. A research assistant presliced the pizza in sixteenths and weighed pizza before and after presentation to the participant. Any remaining food was added to the postpresentation weight. Participants were not informed that food consumption was being monitored. When a pizza was presented, the participant was told to have as much or as little as he/she likes and given up to 30 min to eat. Twelve ounces of water was also presented to each participant, and the amount of water consumed was recorded as well. Participants were not allowed to eat or drink any other food or beverages.

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Self-report scales of satiety and fatigue

After completing tasks for the respective visit and before the presentation of food, participants were asked to self-report hunger and satiety levels using visual analog scales. Scales were 100 mm in length and anchored by opposite meaning phrases at each end. Participants were asked to report on “How hungry are you?” “How full are you?” “How much can you eat?” and “What is your desire to eat?” Participants were instructed to make a mark on the line to indicate their response. Distance from the left most point on the line (corresponding to a response of 0) and the participant’s mark was measured. This distance in millimeters was recorded as the response.

Participants were also asked to respond on a five-option Likert-type scale to indicate whether they were “worn out,” “listless,” “fatigued,” “exhausted,” “sluggish,” “weary,” and “bushed.” Responses on the five-option Likert-type scale ranged from “not at all” to “extremely.” A number between 1 and 5 was coded according to the participant’s selection.

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Estimation of energy expenditure during MW + R or MW + E

Estimates of energy expenditure of exercise during the MW + E condition was based on V˙O2submax and heart rate values obtained during screening and the assumption of 5 kcal·L−1 of oxygen (17). Aerobic energy expenditure calculations were only applied to time spent in work intervals. Postexercise measured blood lactate was used to estimate anaerobic energy expenditure. The formula for estimate of lactate energy expenditure was lactate postexercise − lactate preexercise × 0.027 × measured bodyweight (11). The estimates for aerobic energy expenditure and anaerobic energy expenditure were summed to create an estimate of overall energy expenditure. This is likely a conservative measure of the energy expenditure during the high-intensity interval exercise bout and is only intended as a rough estimation for comparing differences in energy balance between groups. Energy expenditures of the rest period during the MW + R condition were calculated with the revised Harris–Benedict equation (31). The estimation of energy expenditure during a 15-min rest period was subtracted from the estimated energy expenditure of exercise to obtain an overall estimate of energy expenditure in the MW + E group above and beyond energy expenditure of the MW + R group.

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Statistical analyses

Power calculations were based on caloric intake reported in previously published literature (5,7). A one-way ANOVA or chi-square test, dependent on variable type, was used to assess potential group differences. A one-way repeated-measures ANOVA was used to assess changes in blood glucose and lactate in the MW + E protocol. A two (time and within-person variable) by two (group and between-person variable) repeated-measures ANOVA was run to assess differences in caloric intake between BR and MW + R or MW + E and differences between groups. Post hoc t-tests with Bonferroni correction were conducted on contrasts of interest. A t-test or paired t-test was run to analyze differences in overall energy balance and self-report measures of satiety and fatigue. Descriptive statistics are presented as mean ± SD, and results for variables of interest are presented as mean ± SE. SPSS version 22 was used for all analyses and α was set at 0.05.

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RESULTS

Forty participants total (19 for MW + R and 21 for MW + E) were randomized to an experimental protocol; one was excluded due to error during testing and the other due to being a statistical outlier (greater than 3 SD). All analyses were conducted with the remaining 38 participants (MW + R = 18 and MW + E = 20). Descriptive statistics and comparisons of groups are presented in Table 1. Groups were not significantly different for age, sex, BMI, estimated percent body fat, measured V˙O2submax, self-report of exerciser, or nonexerciser. Percent body fat and other physiological factors (i.e., BMI, waist circumference, fitness level, etc.) were assessed as a covariate and did not affect overall outcomes.

TABLE 1

TABLE 1

Results from the repeated-measures ANOVA indicated a significant time–group interaction for caloric intake, F(1,36) = 4.84, P = 0.034. Participants in the MW + R group consumed approximately 100 additional kilocalories after mental work (633.3 ± 72.9) compared with their BR visit (533.9 ± 67.7), paired t(17) = −2.58, P = 0.020. Participants in the MW + E group decreased consumption by an estimated 25 kcal (BR visit = 456.5 ± 64.2, MW + E visit = 432.3 ± 69.2); this was not a statistically significant difference. Estimated caloric intake values are presented in Figure 1. There were no significant main effects of time or group.

FIGURE 1

FIGURE 1

Self-report satiety and fatigue did not significantly differ between groups. Participants in the MW + R group responded with lower values to “How much can you eat?” in the MW + R visit (57.89 ± 14.36) than that in the BR visit (64.72 ± 13.62), paired t(17) = 2.55, P = 0.021. All other self-report satiety and fatigue ratings were not statistically different between the BR and the MW + R visits. Participants in the MW + E group reported higher levels of “fatigued” after the MW + E visit (2.40 ± 0.94) than the BR visit (1.70 ± 0.98), paired t(19) = −3.20, P = 0.005. Participants in the MW + E group also responded with higher levels of “worn out” after the MW + E visit (2.45 ± 0.94) compared with the BR visit (1.65 ± 0.88), paired t(19) = −3.238, P = 0.004. All other self-report satiety and fatigue ratings were not statistically different between the BR and the MW + E visits.

Estimated energy expenditure of the interval exercise bout was calculated for participants in the MW + E condition. Energy expenditure calculations were based on V˙O2submax, heart rate, and blood lactate. The average estimated energy expenditure of the exercise protocol was 90.2 ± 8.2 kcal. Energy expenditure of the 15-min rest period was also calculated using a revised Harris–Benedict formula. Average estimated energy expenditure of the rest portion of the visit was 16.8 ± 0.7 kcal.

Compared with the BR visit, participants in the MW + R group were in positive energy balance by an estimated 99.4 ± 38.5 kcal. Participants in the MW + E group consumed less calories than during their BR visit, and factoring in the estimated energy expenditure of exercise while also subtracting energy that would have been expended at rest, participants in MW + E were in negative energy balance by an estimated −98.5 ± 41.6 kcal. Overall, the MW + R and MW + E group differed in estimated energy balance by 198.0 ± 57.0 kcal, t(36) = 3.47, P = 0.001. These values may vary with more precise calculations of energy expended at rest and exercise. This difference in estimated energy balance is illustrated in Figure 2.

FIGURE 2

FIGURE 2

Blood glucose and lactate values are presented in Figure 3. Results for blood samples are presented for 18 of the 20 participants in the MW + E group due to a change in study protocol that occurred after two participants had completed the MW + E visit. Blood glucose remained stable across all three time points. Lactate significantly differed across the three measurement points F(1, 17) = 24.03, P = 0.000. Post hoc testing indicated lactate did not significantly change between the first and the second measurement but did significantly increase after exercise, paired t(17) = −4.90, P = 0.000 for time 1 to time 3, and paired t(17) = −3.77, P = 0.002 for time 2 to time 3. Changes in lactate and glucose were not significantly associated with changes in eating behavior between visits.

FIGURE 3

FIGURE 3

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DISCUSSION

Overall, findings suggest exercise may prevent a surplus of energy intake after mental activity. There was a significant differential effect in energy intake between participants that did or did not participate in exercise after mental work. After mental work, participants consumed more calories than after a rest condition, resulting in a positive energy balance. Participants that exercised after mental work did not consume additional energy and were believed to be in negative energy balance. These findings suggest exercise’s anorexigenic effects may decrease energy intake after activities with orexigenic effects. These findings corroborate findings by other research groups (5,7,16,21,26) and build on them by being the first to report a statistically significant difference in energy intake between participants completing mental work and a meal, or mental work and exercise then a meal.

Reasons for the observed changes in energy intake in the MW + R and MW + E protocols are not entirely understood. One possible explanation of exercise’s effects on energy intake after mental work may be due to the brain’s use of substrates. The brain is dependent on limited glucose, glycogen, and lactate for energy, and these energy levels are tightly regulated (29,30). Mentally demanding tasks increase brain activity, which uses energy stores (6,14,23,33,38). It is possible that hyperphagia after mental tasks is due to the brain attempting to replace energy supplies. Chaput et al. (5) also reported fluctuations in glucose and insulin concentrations during a mental work condition, but not during a rest condition. Future investigations could assess glucose and insulin as a potential mechanism for the observed effects. Fluctuations of glucose and lactate have been demonstrated to affect acute appetite. These observations are best documented through Mayer’s glucostatic theory (24), where a rise in plasma glucose concentrations could serve as a satiety signal. Changes in glucose were not observed in this study possibly because of collection methodology, and insulin was not measured in this protocol, although we did observe significant increases in lactate as a result of exercise.

Exercise’s affect on eating behavior has also been well studied. We chose exercise as a possible means to offset hypherphagia after mental work due to previous research demonstrating exercise sessions of varying intensity and lasting an hour or less decreased desire for food and calorie intake (4,9,12,19,27,35,37). Additional studies have reported decreased energy intake in addition to the energy expense of exercise, which augments the negative energy balance results of exercise (16,18,26). The mechanisms of exercise’s appetite suppressing effects are unclear, although much emphasis has been placed on exercise’s effect on hunger and satiety hormones. However, there are numerous documented influences on eating behavior, and any number of those influences (e.g., hedonic value of food, reduced inhibition, palpability, and other behavior or social reasons) could have affected our results as well.

An acute, intense bout of exercise can increase blood glucose and lactate concentrations (20,39,40). Blood glucose levels did not increase after exercise as hypothesized, but blood lactate did. Because insulin action plays a role in transport of glucose across the blood–brain barrier and exercise is known to improve glucose uptake, it is possible that brain glucose may have increased despite no change in the blood glucose. Timing and location of blood sampling may have affected blood glucose results. Given the study methods, it is not possible to do more than associate blood lactate increases with decreases in food consumption, but the measurement of brain lactate, glucose, and glycogen in future studies warrants consideration. In addition, other influences on appetite should be considered and measured in future studies.

Exercise and mental work’s effects on energy intake are possibly due to the brain’s need to replenish fuel sources, or due to decreases in self-control, attention, etc. Not only would a person be drawn to food for increasing glucose levels, but reduced inhibition may lead to consumption of more food. That is, food consumption may occur for energy demand purposes or may also be due to reduced willpower to resist a food option that is typically viewed as appealing but unhealthy (15). This may especially be the case in our current abundant food environment, and exercise may aid against positive energy balance not only through increased energy expenditure but also by affecting caloric intake.

The current findings are limited to an acute setting and comparisons between two ad libitum meal sessions with only one food type. Participants were also assigned to different intervention procedures, so the lack of a full cross-over design and variability between participants may have affected the outcomes, but the significant findings indicate a possible relationship between mental work, exercise, and energy intake. Figure 2 includes an estimation of these energy balance differences, but we did not assess energy expenditure in all conditions. Future studies should include a more accurate measurement of energy expenditure in all settings. Future studies should also include more precise measurements of glucose, lactate, and insulin levels in all conditions. Other factors that have previously been demonstrated to relate to eating behavior such as sex, restrained eating, BMI, and other biomarkers may be highly valuable in understanding the mechanisms for the observed outcomes. In addition, although attempts were made to standardize participant behavior before each visit, caloric intake at breakfast or energy expenditure before arriving in the laboratory was not completely controlled. The follow-up measurement of food intake would also be beneficial to determine whether compensation occurs.

In conclusion, a high-intensity exercise bout after mental work may offset increased energy intake. Exercise after mental work, instead of food consumption, may serve as a way to regulate energy intake. The modern work environment is highly sedentary and cognitively demanding. The cognitive demand may influence the individual’s appetite and lend itself toward positive energy balance. If an individual seeking to take a break from mental work chooses to participate in exercise before consuming food, this may prevent the positive energy balance. This relationship between mental work, exercise, and energy intake may be impactful in reducing the positive energy balance responsible for modern obesity trends.

The authors thank David B. Allison, David Bryan, Brandon Kane, and Gabrielle Pybus. Also, this work was supported by the National Heart, Lung, and Blood Institute (grant no. T32HL105349) and a pilot funding from the Department of Human Studies at the University of Alabama at Birmingham. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Heart, Lung, and Blood Institute, the National Institutes of Health, or the University of Alabama at Birmingham.

The authors have no conflicts of interest to disclose. The results of the present study do not constitute endorsement by the American College of Sports Medicine.

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Keywords:

INTERVAL EXERCISE; EATING; APPETITE; MENTAL FATIGUE; ENERGY BALANCE

© 2016 American College of Sports Medicine