D-32 Free Communication/Poster - Epidemiology of Physical Activity and Health in Older Adults Thursday, June 2, 2016, 1: 00 PM - 6: 00 PM Room: Exhibit Hall A/B
PURPOSE: To investigate longitudinal associations of self-rated physical fitness and estimated maximal oxygen uptake with all-cause and cause-specific mortality risk, taking into account the modifying effects of age, gender, physical activity and chronic conditions.
METHODS: Data comprise the National FINRISK Prospective Study Cohort 1972-2007 with endpoints on all-cause and cause-specific mortality data from the Finnish National Register of Causes of Death over a follow-up from 3 to 38 years. A total of 62,204 participants reported information on perceived physical fitness level and a subsample of 4,947 persons underwent a non-exercise test on maximal oxygen uptake in 2002. From the analyses, we excluded persons with prevalent severe diseases at baseline or persons who died within two years or who developed dementia within 5 years after the follow-up had started. Cox proportional hazards models were used with adjustments for sex, education, body mass index, physical activity, smoking, severe chronic conditions and study year.
RESULTS: During the mean follow-up of 20.0 (SD±11.2) years, altogether 14,723 (23.7%) participants died. Mortality rates per 1000 person-years for participants with good, satisfactory and poor self-rated fitness were 7.5, 12.7 and 19.6, respectively. In the fully adjusted models, poor (HR 1.9, 95%CI 1.8-2.0) and satisfactory (HR 1.4, 95%CI 1.3-1.5) self-rated fitness predicted all-cause mortality when compared to the reference group of good fitness level. Poor and satisfactory fitness levels associated directly with mortality due to cardiovascular, cerebrovascular and respiratory diseases, trauma, infections, dementia and cancer when compared to good fitness level in the fully adjusted models. In men, higher estimated maximal oxygen uptake associated with lower risk of lung cancer mortality (HR 0.8, 95%CI 0.7-0.96) when compared to low fitness in the fully adjusted models.
CONCLUSION: Self-rated fitness reflects a combination of unfavorable biological and lifestyle-related factors that increase mortality risk. Self-rated fitness is a feasible non-invasive method for the entire population and thus should be used more actively for preventive activities in health care.