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D-32 Free Communication/Poster - Epidemiology of Physical Activity and Health in Older Adults Thursday, June 2, 2016, 1: 00 PM - 6: 00 PM Room: Exhibit Hall A/B

Is Cardiorespiratory Fitness Still as Relevant for Mortality Risk in the Statin Era?

1988 Board #140 June 2, 3

30 PM - 5

00 PM

Farrell, Stephen W. FACSM; Radford, Nina B.; DeFina, Laura F.; Leonard, David S.; Finley, Carrie E.; Barlow, Carolyn E.; Willis, Benjamin L.; Haskell, William L. FACSM

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Medicine & Science in Sports & Exercise: May 2016 - Volume 48 - Issue 5S - p 553
doi: 10.1249/01.mss.0000486661.12762.86
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Risk factor prevalence, screening guidelines, and the treatment milieu for various causes of mortality have changed significantly over the past several decades.

PURPOSE: To determine if the relationship between cardiorespiratory fitness (CRF) and all-cause mortality has changed over this time period

METHODS: Participants in the present study included 44,063 apparently healthy men between the ages of 20 and 80 years who completed a baseline examination including a maximal treadmill exercise test at the Cooper Clinic in Dallas, Texas between 1971 and 2005. Participants were divided into two groups: Men in Cohort 1 were examined during 1971-1987 and followed for mortality through 1992 (pre-statin era), while men in Cohort 2 were examined during 1988-2005 and followed for mortality through 2010 (statin era). All-cause mortality incidence curves across CRF levels (maximal METS) for both cohorts were developed.

RESULTS: The distributions of maximal MET level were very similar in both cohorts. Additionally, an inverse relation between CRF and mortality incidence was observed in both cohorts. However, smoking and BMI-adjusted mortality incidence was significantly higher in the earlier cohort for men who achieved 5-15 METS (p<0.05). Beyond 15 METS, there was no significant difference in mortality incidence between the cohorts.

CONCLUSION: Despite significant changes in risk factor prevalence, screening guidelines, and the treatment milieu for various causes of mortality, CRF remains a strong and independent risk factor in men. All men are urged to maintain a healthy level of CRF by meeting public health guidelines for physical activity.

© 2016 American College of Sports Medicine