Secondary Logo

Journal Logo

High-Intensity Interval Training with Energy Restriction Preserves Lean Tissue and Improves Glucose Tolerance in Obesity: 3369 Board #2 June 3, 315 PM - 515 PM

Harley, Rachel A.; Halbrooks, Jacob E.; Nagy, Timothy R.; Fisher, Gordon; Hunter, Gary R. FACSM; Plaisance, Eric P.

Medicine & Science in Sports & Exercise: May 2016 - Volume 48 - Issue 5S - p 948–949
doi: 10.1249/01.mss.0000487841.34966.34
F-61 Thematic Poster - Energy Balance and Weight Control Friday, June 3, 2016, 3:15 PM - 5:15 PM Room: 110

University of Alabama at Birmingham, Birmingham, AL.


(No relationships reported)

Energy restriction (ER) reduces body weight (BW) and adiposity, but is often less than expected due to hypometabolism produced by reductions in lean body mass (LBM). A comparable energy deficit created by combining ER and exercise energy expenditure (EE) has been shown to attenuate the reduction in EE produced by ER. Continuous moderate-intensity training (MIT) is commonly used to sustain energy balance or expedite weight loss, but high-intensity interval training (HIIT) may produce greater results.

PURPOSE: The purpose of this investigation was to determine if HIIT preserves LBM and improves energy metabolism to a greater extent than MIT in the presence of ER.

METHODS: Thirty-two 5-wk old male C57BL/6J mice were placed on a 45% kcal high-fat diet (HFD) for 11 weeks (ad libitum). Mice were then randomized to 4 groups for 14 weeks: 1) HFD (n = 8; remain on HFD); 2) HFD with 25% ER (n = 8); 3) HFD with 25% energy deficit induced by 12.5% ER and 12.5% EE through HIIT (n = 8); and 4) HFD with 12.5% energy deficit induced by 12.5% ER and 12.5% EE through MIT. HIIT consisted of 9-12 intervals of 2.5-minutes of treadmill running at 0.18-0.30 m/s with 1 minute of passive recovery between intervals. MIT consisted of 35-50 minutes of continuous treadmill running at 0.13-0.21 m/s. Body composition was assessed by Quantitative Magnetic Resonance (QMR) and resting energy expenditure (REE) by indirect calorimetry. Glucose tolerance tests were performed on all groups at 1.0 g/kg BW (i.p.), while insulin tolerance tests were performed at 0.75 mU/g BW (i.p.).

RESULTS: HFD increased BW from 20.2±0.2 to 38.8±0.8 g (92.3% increase in BW). REE was 11.2% lower in the ER group compared to Control (73.0±1.7 to 64.8±1.6 kJ/hr LBM, p<0.05). HIIT, but not MIT, preserved LBM and rescued ER-mediated reductions in REE. The increase in LBM was associated with improvements in glucose tolerance and insulin sensitivity.

CONCLUSION: Twenty-five percent ER produced reductions in LBM and REE, whereas HIIT preserved LBM, increased REE and improved glucose tolerance and insulin sensitivity. These results suggest that HIIT may produce a hypermetabolic state in the presence of ER, which could lead to long-term success in weight loss interventions. Supported by UAB Department of Human Studies Pilot Award.

© 2016 American College of Sports Medicine