D-26 Free Communication/Poster - Carbohydrate Metabolism in Health/Disease Thursday, June 2, 2016, 1: 00 PM - 6: 00 PM Room: Exhibit Hall A/B
A growing body of literature suggests that differences in metabolic responses to nutritional challenge can be demonstrated when the postural condition of the individual is changed from sitting to standing. Previously we have shown striking differences in the response to a glucose tolerance test between sitting and a proxy for standing.
PURPOSE: To compare glucose and lipid clearance, in healthy individuals in response to a high fat commercial breakfast meal performed under standard sitting conditions or while during a proxy for standing (0.5 mph walk on an Active Workstation).
METHODS:: 9 individuals, 3 females and 6 males (87.9±20.1 kg.) performed two tests (sit & 0.5 mph walk). After a minimum of an 8-hour fast a baseline glucose, total cholesterol, triglycerides (Trigly), HDL and LDL measurements were obtained. Subjects then ingested a fast food breakfast containing a minimum of 20 grams of fat. In a counterbalanced manner, subjects either spent the next two hours sitting or walking at 0.5 mph (a proxy for standing) on an Active Workstation. A blood sample (finger stick) was obtained every 30 min for the next two hours (Cholestech®).
RESULTS: The Trigly (Mean±SD) levels (mg %) showed a significant rise across time in the sitting condition: 109.7±34.1 to 151±47.3) vs a non-significant rise in the 0.5 mph group: 120±49.2 to 148.5±69.3. Glucose responses (mg %) across time were similar in both groups, however the sitting group showed a significantly higher level at the 30 min sample (112.5±10.0 vs 101.5±15.5, t= 2.1, df=8, p<.03).
CONCLUSIONS: These results provide limited support for the impact of very low levels of physical activity (proxy for standing) on metabolic responses to a meal. Two hours may be too short an interval to detect the maximum effect of the meal and posture on lipid changes. The results are consistent with the potentially deleterious effects of sitting.