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D-26 Free Communication/Poster - Carbohydrate Metabolism in Health/Disease Thursday, June 2, 2016, 1: 00 PM - 6: 00 PM Room: Exhibit Hall A/B

Effects of Postmeal Exercise on Postprandial Glucose in People Treated with Metformin

1898 Board #50 June 2, 3

30 PM - 5

00 PM

Erickson, Melissa L.; McCully, Kevin K. FACSM; Little, Jonathan; Jenkins, Nathan

Author Information
Medicine & Science in Sports & Exercise: May 2016 - Volume 48 - Issue 5S - p 522
doi: 10.1249/01.mss.0000486571.23064.0f
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Postprandial hyperglycemia is associated with the development of macrovascular and microvascular diseases. Thus, there is a need for effective treatments that reduce postprandial hyperglycemia. Metformin is used clinically to reduce blood glucose, however, hyperglycemia is not always adequately controlled with metformin. It is currently unknown how the combination of metformin and postmeal exercise affects postprandial glucose.

PURPOSE: Examine the effects of postmeal exercise on postprandial glucose in people being treated with metformin.

METHODS: 2-hr area under the curve after a standardized breakfast meal and peak postprandial glucose, assessed with continuous glucose monitoring, were compared in sedentary versus postmeal exercise conditions in 6 people treated with metformin. Postmeal exercise began 30 minutes into the postprandial phase and consisted of 5 x 10 minutes bouts of treadmill walking at 60% maximal oxygen uptake.

RESULTS: 2-hr area under the breakfast curve was 27% lower after postmeal exercise (sed: 1315 ± 299 vs. ex: 998 ± 235 mmol/L x 2 hr; p = 0.008). Peak glucose was 28% lower after postmeal exercise (sed: 11.8 ± 2.9 vs. ex: 8.9 ± 1. mmol/L; p = 0.01). Postmeal exercise lowered postprandial glucose levels below the current International Diabetes Federation postmeal recommendation of 8.8 mmol/L in 3 of 6 participants.

CONCLUSION: Postmeal exercise resulted in postprandial glucose reduction in people being treated with metformin, and therefore may be a useful approach for managing postprandial hyperglycemia.

Funded by the University of Georgia College of Education, Office of the Vice President for Research, and the Mary Ella Lunday Soule Scholarship.

© 2016 American College of Sports Medicine