C-18 Thematic Poster - Reduction of Metabolic Syndrome and Chronic Disease Thursday, May 29, 2014, 8:00 AM - 10:00 AM Room: 110 B
Mexican American women have the highest prevalence of metabolic syndrome compared to other racial and ethnic groups. Metabolic syndrome is characterized by a clustering of risk factors (hyperglycemia, hypertension, and dyslipidemia) that most likely results from insulin resistance. Insulin resistance is often associated with increased circulating VLDL-triglycerides, which can remodel lipoproteins resulting in smaller, more dense LDL particles thought to be especially atherogenic.
PURPOSE: It was the purpose of this study to examine the associations between insulin sensitivity and lipoprotein particle size in Mexican American women.
METHODS: 27 Mexican American women (mean ± SD: age (y) 36 ± 13; BMI (kg/m2) 30.6 ± 6.4; body fat (%) 46.7 ± 6.0) volunteered to participate. A fasting blood sample was drawn for determination of glucose, insulin, lipid profile (HDL, LDL, and TG), lipoprotein particle size concentration, adiponectin, and high molecular weight (HMW) adiponectin. Insulin sensitivity (GIR) was determined by euglycemic hyperinsulinemic clamp technique. Pearson’s correlation coefficients and Spearman’s rho were used to determine the relationships between the variables. A multiple stepwise regression analysis was used to determine those variables that had the greatest influence on small LDL particle concentration.
RESULTS: Small LDL particle concentration was significantly correlated (P < 0.05) with GIR (r = -0.70), waist circumference (r = 0.50), % body fat (r = 0.40), HMW adiponectin (r = -0.49), total HDL (r = -0.51), total TG (r = 0.68), and particle size of both LDL (r = -0.65) and HDL (r = -0.83). Multiple stepwise regression revealed that 79% of the variance in small LDL particle concentration was explained by GIR, LDL size (nm), total HDLs (mg/dL), and total TGs (mg/dL) (P < 0.001).
CONCLUSIONS: In our sample, approximately 60% of circulating LDL concentration was small LDL and there was an inverse association with small LDL particle concentration and GIR. Small LDL particle size has been shown to be associated with increased atherogenesis and insulin resistance.
Funded by the USDA – Colorado Agricultural Experiment Station