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Association between Physical Fitness and Cognitive Decline in a Sample of Older Persons: 811 Board #226 May 28, 200 PM - 330 PM

han, jinhee; Cho, Jinkyung; Lee, Jaeeun; Lee, Inhwan; Park, Junghwan; Kong, Jiyoung; Kang, Hyunsik

Medicine & Science in Sports & Exercise: May 2014 - Volume 46 - Issue 5S - p 215–216
doi: 10.1249/01.mss.0000493831.90796.0f
B-37 Free Communication/Poster - Physical Activity and Cognition Wednesday, May 28, 2014, 1:00 PM - 6:00 PM Room: WB1

sungkyunkwan university, suwon, Korea, Republic of.

(No relationships reported)

PURPOSE: In a cross-sectional design, we investigated the relationship between physical fitness and mild cognitive impairment (MCI) in a sample of older persons (aged from 60 to 88 yrs) recruited from our local community.

METHODS: Subjects (75 men/155 women) underwent body composition assessment, mini-mental state examination (MMSE), and senior fitness test. Components of the senior fitness test included upper- and lower-body strength, upper- and lower-body flexibility, agility, and aerobic fitness, as previously stated (J Aging & Physical Activity, 2002, 10, 110). Fasting blood was collected to assess risk factors including glucose, lipids, Aβ42 and Aβ40. Based on age- and sex-standardized fitness distribution, the subjects were classified as low (lower 25 percentile)-, moderate (middle 50 percentile)-, and high (upper 25 percentile)-fit groups. This study was reviewed and approved by the Institutional Review Board for human study.

RESULTS: The Kruskal-Wallis tests showed linear decreases for age (low: 74.3±7.2 yrs; moderate: 70.4±5.2 yrs; high: 69.0±4.8 yrs; p<0.001) and LDL-C (low: 78.9±29.0 mg/dL; moderate: 79.3±26.5 mg/dL; high: 67.7±27.1 mg/dL; p=0.024) across the standardized fitness levels. In particular, a linear increase for MMSE score (low: 25.2±3.4; moderate: 26.2±2.6; high: 27.3±2.2; p<0.001)) was found across the standardized fitness levels. Logistic regression analyses showed that high-fit group (OR of 0.166 and 95% CI of 0.048∼0.576) was less likely to have MCI than low-fit group (OR=1), even after controlled for age, sex, and the measured risk factors (p=0.005). The ORs for having MCI were not different between low (OR=1)- and moderate-fit (OR of 0.524 and 95% CI of 0.236 ∼ 1.164) (P=0.113).

CONCLUSION: The findings of the study suggest that physical activity and/or fitness should be promoted as a preventive means against cognitive decline with aging.

This study was supported by the Korean Government Research Foundation funded by the Korean Government (NRF-2013S1A2A2034953).

© 2014 American College of Sports Medicine