Hamstring reinjury rates have been reported as high as 30% within the same season for Australian Footballers (19). Incomplete recovery and inadequate rehabilitation have been suggested as explanations for this high reinjury rate (7). In particular, a residual strength deficit in the injured limb is considered one of the primary causes (8,9,23,24,30); however, the extent of strength loss at the time of return to sport (RTS) has not yet been investigated.
Persistent strength deficits have been observed in individuals with recurrent hamstring injuries, despite returning to athletic competition (9). For example, in comparison to the unaffected limb, a 10% reduction in concentric peak torque was noted in subjects having experienced injury 2–12 months prior, with a 22% strength deficit during eccentric testing (9). In addition to reduced peak torque production, the knee flexion angle at which peak concentric torque occurs has been found to increase in previously injured limbs (4). This finding suggests that torque production at longer muscle lengths may be compromised. Considering that the susceptibility for sustaining a muscle strain injury is greatest during eccentric loading in a lengthened position (10,11,17,18,22), these observed strength deficits, particularly at longer muscle lengths, likely increase reinjury risk.
Atrophy of the previously injured muscle may also contribute to the persistent strength loss (9). A substantial reduction in biceps femoris long head volume has been found in >50% of individuals with a prior injury despite having returned to athletic competition (25). Although the rehabilitative process plays an important role in the return of muscle size after the acute injury (25), changes in the relative amount of connective tissue may also impede recovery (15). Scar tissue adjacent to the site of original injury has been observed as early as 6 wk (7) and as late as 23 months after injury (25). The presence of scarring has been shown to alter the in vivo muscle contraction mechanics, generating localized regions of high tissue strains near the site of prior injury of the biceps femoris (26). The presence of scar tissue may increase the overall stiffness of the musculotendon unit (5,14), although this idea has not been scientifically tested. It is likely that, together, these changes in muscle morphology after a hamstring strain injury may compromise the return of normal muscle function.
The purpose of this study was to characterize isokinetic hamstring strength and morphology at the time of RTS after a controlled rehabilitation program for an acute strain injury. Tests were then repeated 6 months after RTS to provide additional insights into the recovery process over time. This study provides a unique understanding of the extent of healing at the time of RTS and how this healing progresses over the following 6 months. We hypothesized that, at RTS, the injured muscle would display weakness and associated changes in hamstring muscle morphology based on magnetic resonance imaging (MRI).
Twenty-five recreational athletes (20 male and 5 female; age = 24 ± 9 yr, height = 1.7 ± 0.5 m, weight = 73.8 ± 25.8 kg) participated in the study. All subjects sustained an acute hamstring strain injury and completed a controlled rehabilitation program. Subjects were recruited from the University of Wisconsin Health clinics and University of Wisconsin recreation facilities. To qualify, subjects needed to be 16–50 yr and involved in athletics a minimum of 3 d·wk−1. The subjects must have sustained an acute, sudden-onset hamstring injury within the prior 10 d and display two or more of the following symptoms: palpable pain along any of the hamstring muscles, posterior thigh pain without radicular symptoms during a straight leg raise, weakness with resisted knee flexion, or pain with resisted knee flexion. Exclusion criteria included complete hamstring muscle disruption (grade 3) or avulsion, posterior thigh pain originating from another source (e.g., inguinal or femoral hernia, nerve entrapment, lumbosacral pathology), or any comorbidity that might prevent participation in a rehabilitation program. Each subject or parent/guardian provided written informed consent before testing, in accordance with the University of Wisconsin’s Health Sciences Institutional Review Board.
After enrollment, subjects immediately began a controlled rehabilitation program under the supervision of the same physical therapist (M.A.S.). The exercises included in the rehabilitation program were the same as those previously published (3,12). Each subject continued the rehabilitation program until established RTS criteria were met, including no significant pain with straight leg raise, full isometric hamstring strength against manual resistance in prone at 90° and 15° of knee flexion, no tenderness to palpation, and no apprehension during full effort, sport-specific movements. Once cleared to RTS by the treating physical therapist, each subject underwent an MRI examination and isokinetic strength assessment; these measures were repeated 6 months later. Subjects were encouraged to continue the rehabilitation exercises (three times per week for 8 weeks) on an independent basis; rehabilitation compliance after RTS was not monitored.
Subjects were positioned on an isokinetic dynamometer (Biodex Multi-Joint System 2; Biodex Medical Systems, Inc., Shirley, NY) such that the hip was flexed to 90°, and the dynamometer and knee joint axes were aligned. Strapping was used over the shank, thigh, and waist to minimize secondary joint movement. Each subject performed maximum effort knee flexion/extension testing through full range of motion during two conditions: concentric at 60°·s−1 (5 repetitions) and concentric at 240°·s−1 (15 repetitions). Eccentric knee flexion testing at 30°·s−1 (3 repetitions) was also performed with the final 13 subjects because this test was added after the study had begun. Before each test, subjects received four submaximal practice trials. Joint angle and torque were recorded after being corrected for gravity. Full knee extension was defined as 0°.
Peak torque and angle-to-peak torque for each testing condition were calculated consistent with Brockett et al. (4). All analyses were limited to the repetitions at each speed containing the highest peak torque values (3 repetitions at 60°·s−1, 12 repetitions at 240°·s−1, and 2 repetitions at 30°·s−1). Torque–angle curves from the select repetitions at each speed were compiled and sorted in relation to movement direction (i.e., flexion/extension) and knee flexion angle. This resulted in one torque–angle curve for each subject, speed, and direction. Next, every successive block of nine data points from the compiled torque angle curve was replaced with an average value. Finally, for each subject, speed, and direction, a second-order polynomial curve was fit to the torque data that were within 10% of the peak torque measurement for that particular condition. Peak torque and angle-of-peak torque were determined from the resulting polynomials. Work was calculated from 0° to 90° of knee flexion by integrating knee flexion torque with respect to time. In addition, the mixed hamstring-to-quadriceps ratio (H:Q) was calculated as hamstring eccentric peak torque at 30°·s−1 relative to quadriceps concentric peak torque at 240°·s−1 (19).
Images were obtained for each subject on a 1.5T Twin Speed magnetic resonance scanner (General Electric Healthcare, Milwaukee, WI) using a phased array torso coil. Each MRI examination included three scans: iterative decomposition of water and fat with echo asymmetry and least-squares estimation (IDEAL) combined with three-dimensional spoiled gradient echo imaging (20), T2-weighted fat-suppressed fast spin-echo coronal scan, and T2-weighted fat-suppressed fast spin-echo axial scan. T2 imaging details were as follows: IDEAL coronal three-dimensional slab, TR = 12.5 ms, three echoes (one echo per TR) with TE = 4.4, 5.0, and 6.6 ms, 15° flip angle; matrix, ±41.7 kHz bandwidth, 384 × 256 matrix with 46 × 46 cm field of view with 84 slices, and 1.4 mm slice thickness for a true spatial resolution of 1.2 × 1.8 × 1.4 mm3 (interpolated to 0.9 × 0.9 × 7 mm3). Water and fat images were created using homodyne reconstruction performed online (21,31). Coronal T2-weighted scan—4-mm slice thickness, 4.4-mm slice interval, 512 × 512 matrix, 90° flip angle, and 2200/9.7 TR/TE. Axial T2-weighted scan—5-mm slice thickness, 5-mm slice interval, 256 × 256 matrix, 90° flip angle, and 3200/89 TR/TE.
The two MRI examinations were analyzed by the same investigator (M.J.T.) at different time points to avoid biased measurements. The total injured area over all muscles was determined at the level where the injury had the largest absolute axial cross-sectional area. Specifically, the cross-sectional area of the injury was calculated from the mediolateral width (ML) and anteroposterior depth (AP) using the formula, 0.25π × ML × AP (2,7,24,27,30). In addition, muscle and tendon–scar volumes of the biceps femoris long head (BFLH), biceps femoris short head (BFSH), semitendinosus (ST), and proximal conjoint biceps femoris and semitendinosus tendon (BFT) were determined at both time points and for both limbs by the same investigator (J.L.S.) using manual segmentation (Mimics Software; Materialize Corp., Ann Arbor, MI) (Fig. 1). The structure boundaries were manually outlined on each coronal slice for muscles and axial slice for tendons in which the structure of interest was present. Intraobserver variability for this technique has been reported at <5% for both muscle (13,29) and tendon (25). Volume was then calculated by summing the cross-sectional area of each slice and multiplying by the interslice distance. Absolute muscle volumes were analyzed for the BFLH, BFSH, and ST, whereas the percent difference between limbs at each time point was assessed for the BFT because of its smaller comparative size and potential for error.
Three subjects did not undergo testing at the 6-month follow-up because they experienced an injury after RTS during sports participation (two hamstring strains, one anterior cruciate ligament tear). Only the complete data sets from the 22 subjects were included in the analysis, with the exception of the H:Q peak torque ratio, which was based on only 13 subjects. The outcome measures analyzed included peak torque, angle-of-peak torque, work (60°·s−1 and 240°·s−1), H:Q peak torque ratio, muscle volumes (BFLH, BFSH, and ST), and tendon volumes (BFT). Two-factor repeated-measures ANOVA (limb-by-time) were performed to compare all outcome measures (P < 0.05), except BFT volumes were compared over time using a dependent t-test. Post hoc testing was performed as needed using Tukey HSD (Statistica 6.0; StatSoft, Inc., Tulsa, OK).
MRI examination at the time of injury revealed 16 subjects sustained an injury primarily to the biceps femoris; 4, to the semimembranosis; and 2, to the ST. The average time away from sport was 26 d (range = 17–49 d).
Isokinetic strength testing at 60°·s−1 revealed significant limb-by-time interactions for peak torque (P < 0.001) and work (P = 0.002; Table 1). On average, the injured limb had a 9.6% deficit in peak torque (P < 0.001) and a 6.4% deficit in work (P = 0.003) at RTS compared to the uninjured limb. These differences resolved by the 6-month follow-up (Fig. 2). The knee flexion angle of peak torque decreased (P < 0.001) for both limbs from RTS to the 6-month follow-up, reflecting a shift in peak torque development to a longer hamstring length (Table 1 and Fig. 2).
Testing at 240°·s−1 showed a main effect for limb, with less peak torque (P = 0.021) and less work (P = 0.006) produced by the injured limb compared to the uninjured limb. No significant difference in angle of peak torque was present between limbs or over time.
The H:Q ratio (30°·s−1 eccentric : 240°·s−1 concentric) revealed a main effect for limb (P = 0.023), with the injured limb having a smaller ratio compared to the uninjured limb (RTS: injured 1.30 ± 0.26, uninjured 1.62 ± 0.31; 6 months: injured 1.39 ± 0.26, uninjured 1.46 ± 0.15).
At the time of RTS, the percent of muscle area showing signs of injury (i.e., T2 hyperintensity) when considering all involved muscles was 20.4% ± 19.4%. By the 6-month follow-up, no evidence of injury was visible on MRI (Fig. 3). The muscle volumes of the ST (4.1%, P = 0.024) and BFSH (6.1%, P = 0.010) for both limbs decreased from RTS to 6-month follow-up, whereas the BFLH volume (3.1%, P = 0.078) showed a similar trend. To obtain a representation of the overall biceps femoris muscle volume, we summed the BFLH and BFSH volumes and found a significant decrease (5.2%, P = 0.010) for both limbs from RTS to 6 months after RTS (Table 2). Only BFSH showed a significant difference between limbs (P = 0.036), with the muscle volume of the injured limb being larger than the uninjured limb over both time points.
At RTS, the BFT volume of the injured limb was 4.4% ± 0.3% smaller than the uninjured limb. At the 6-month follow-up, the injured limb’s BFT volume was 29.9% ± 82.9% larger; however, this change over time was not significant (P = 0.108).
The purpose of this study was to examine the effects of an acute hamstring strain injury on strength and morphology at RTS and after the subsequent 6 months. The injured limb showed a strength deficit at RTS (60°·s−1: peak torque, 9.6%; work, 6.4%) compared to the uninjured limb, with 20% of the cross-sectional area still showing signs of injury on MRI. Six months after RTS, this strength deficit resolved, despite the ST and biceps femoris muscles of both limbs experiencing 4%–5% atrophy.
This study is the first to assess hamstring strength at the time of RTS after a strain injury. The observed strength deficit of the injured limb at RTS is consistent with the 10% deficit reported in individuals having already returned to sport for periods ranging from 2 to 12 months (9). Unlike Croisier et al. (9), our results showed full strength recovery by 6 months after RTS. This difference may be reflective of the greater number of subjects with prior hamstring strain injuries: 46% of the subjects in Croisier et al. (9) compared to only 13% (three subjects) of the subjects in the current study.
The strength deficit present at the time of RTS is likely related to the remaining muscle injury observed on MRI (T2 hyperintensity). On average, 20% of the muscles’ cross-sectional area showed signs of injury at RTS with the MRI performed an average of 26 d after injury (range = 13–49 d). These findings are consistent with those of Askling et al. (2); at 21 d after injury, 26% of the muscle area showed signs of injury, with a reduction to 17% by 42 d after injury. In the current study, there was no evidence of remaining injury on MRI performed at the 6-month follow-up. Thus, it appears that healing progressively continues after RTS and is completed within the subsequent 6-month period.
Given the relationship between muscle size and strength, we anticipated muscle hypertrophy would accompany the strength gains. However, our results showed an average atrophy of 4%–5% in the hamstring muscles of the injured limb from RTS to the 6-month follow-up. This atrophy was not limited to the most involved muscle but was observed in the BFLH, BFSH, and ST, despite the ST being the primary muscle injured in only two subjects and no subjects having primary involvement of the BFSH. Prior work has observed an apparent compensation among agonist muscles after a strain injury. Specifically, a 10% hypertrophy in the BFSH appeared to offset the corresponding 13% atrophy in the BFLH in individuals with a history of strain injury to the BFLH (25). This potential compensation was not observed during the 6-month period after RTS in the current study because both the BFLH and the BFSH showed a similar degree of atrophy. Consequently, another explanation for the observed strength gains must exist, such as neuromuscular influences. Considering the degree of injury still evident on MRI at RTS, a protective neuromuscular inhibition may exist at that time to limit peak torque and minimize reinjury risk. At the 6-month follow-up, all indication of injury observed on MRI had resolved, and we reemphasize that muscle volume had decreased. Therefore, we propose that part of the strength gains over time can be explained by removal of the neuromuscular inhibition during complete muscle healing, regardless of muscle volume changes. Indeed, reduced activation of the hamstring muscles with a corresponding reduction in peak torque has been observed in individuals after a hamstring strain injury (28). However, because we did not collect electromyography data in the current study, we are unable to confirm this relationship.
It has been suggested that the time of RTS after injury is, in part, influenced by psychosocial factors such as fear and apprehension (1,6). For example, increased fear of movement and reinjury has been associated with decreased perceived function in individuals nearing completion of rehabilitation after anterior cruciate ligament reconstruction (6). Specific to athletes with a recent hamstring strain injury, insecurity when performing a ballistic hip motion has been observed at the time of RTS testing, despite having passed common clinical strength and flexibility tests (1). As such, fear or apprehension within our subjects at the time of RTS may partially explain the corresponding reduction in strength. However, we do not believe these psychosocial factors played a primary role because all subjects in our study were required to complete a variety of sport-specific movements at full effort without apprehension before being cleared to RTS and the isokinetic strength testing.
One likely explanation for the observed hamstring atrophy may be that the subjects reported a decrease in athletic participation from RTS to the 6-month follow-up. On average, our subjects reported participating in sports 5.6 ± 1.2 d·wk−1 before injury and only 3.7 ± 2.1 d·wk−1 at the 6-month follow-up. A reduction in activity could also explain the decreased muscle volumes observed in the uninjured limb. Why there was a reduction in activity level is not fully understood because it could suggest residual symptoms or be related to a change in athletic season. Many of the subjects in this study were injured during their in-season athletic play. When the 6-month follow-up testing was performed, the subjects may have been out-of-season and therefore less active.
Earlier research has shown that individuals with a history of multiple hamstring strain injuries display a greater knee flexion angle of peak torque (41°) compared to their uninjured limb (30°) (9). Surprisingly, we did not observe a side-to-side difference in the angle of peak torque at either RTS or the 6-month follow-up. However, two interesting observations were present. First, both limbs displayed an average knee flexion angle of peak torque of approximately 40° at RTS, 10° more flexed than at the 6-month follow-up. Second, the angle of peak torque for both limbs at the 6-month follow-up (∼30°) was consistent with values previously reported among individuals who never incurred a hamstring strain injury (4).
Hamstring-to-quadriceps (H:Q) ratio (30°·s−1 eccentric: 240°·s−1 concentric) values less than 1.05 have been proposed as a predictor of reinjury (8). We observed H:Q values above this criterion in both limbs at RTS and the 6-month follow-up. Although we did not observe a significant limb-by-time interaction (P = 0.120), we did find the H:Q of the injured limb to be consistently smaller than the uninjured limb. It is important to note that eccentric isokinetic testing at 30°·s−1 was added at the midpoint of the study, and only the final 13 subjects completed this testing; thus, further investigation is warranted.
It is widely recognized that scarring accompanies healing after a strain injury. Scar tissue has been observed as early as 6 wk after an initial injury (9) and found to persist on a long-term basis (25). Considering the biceps femoris or ST were the primary muscles injured in 83% of our subjects (n = 19/23), we anticipated the BFT volume would be larger in the injured limb and increase across time between measurement sessions. However, the 35% increase in BFT volume between RTS and the 6-month follow-up was not significant (P = 0.108), primarily because of the large variability in volumes changes observed between subjects.
It has been proposed that the increased knee flexion angle of peak torque in injured muscles is a result of scar tissue formation and the effective shortening of the adjacent muscle fibers (4). Interestingly, we only observed changes in BFT volume in the injured limb, whereas the shift in angle of peak torque was bilateral. Thus, injury-induced scar tissue formation is likely not the sole cause of changes in angle of peak torque. Again, we suggest that neuromuscular influences may be present. Reduced or delayed muscle activation could produce a similar effect, causing peak torque to occur at a greater knee flexion angle as we observed here.
Despite being cleared to RTS, the presence of continued edema and strength deficits suggest that an extended convalescent period may be necessary to achieve full recovery. The required amount of time needed for this to occur is currently unknown. Our findings indicate that recovery occurs by 6 months; however, it is unlikely that this full period is necessary. Future work is needed to more closely identify the time point of recovery. Further, it appears that the battery of clinical tests used in the current study for determining clearance of RTS was inadequate because all subjects in this study were cleared for RTS despite the presence of these residual deficits. Inclusion of objective measures such as isokinetic strength seems warranted in determining readiness of RTS. Although a limited number of reinjuries were observed during the 6-month period of this study, we performed a preliminary comparison of the measures at RTS between those who did and did not sustain reinjury. No significant differences between these subject groups were observed for any of our outcome measures. Thus, the influence that the strength deficits and edema present at RTS have on reinjury risk remains an area of future study.
Certain limitations within the study should be considered when interpreting its findings. We opted to report absolute muscle volumes rather than normalizing the volume of the injured limb to the uninjured limb. Although normalizing would likely reduce the potential error associated with the segmentation process, muscle volume can quickly change with associated changes in physical activity; thus, the uninjured limb would not serve as a proper reference over time. However, because tendon properties are more difficult to change as a result of physical activity (16), we did report normalized tendon volumes.
Our findings indicate that, at the time of RTS after a hamstring strain injury, the injured limb displays a strength deficit compared to the uninjured limb and shows MRI evidence of muscle injury. By 6 months after RTS, the strength deficit and signs of injury are fully resolved while scar tissue exists. Bilateral changes in angle of peak torque appear to occur independent of scar tissue formation, suggesting a neuromuscular influence. The influence of these combined factors on reinjury risk is uncertain at this time.
This work was funded by the National Football League Medical Charities, the National Institutes of Health (1UL2RR025012) and the University of Wisconsin Sports Medicine Classic Fund.
The authors would like to acknowledge Scott Hetzel for his assistance with the statistical analyses.
The authors have no conflicts of interest.
The results of the present study do not constitute endorsement by the American College of Sports Medicine.
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Keywords:© 2013 American College of Sports Medicine
MAGNETIC RESONANCE IMAGING; KNEE FLEXION TORQUE; REHABILITATION; MUSCLE VOLUME