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Non-alcoholic Beer Reduces Inflammation And The Incidence Of Upper Respiratory Tract Infections After A Marathon: 588Board #5 1:00 PM - 3:00 PM

Scherr, Johannes; Nieman, David C. FACSM; Schuster, Tibor; Braun, Siegmund; Wolfarth, Bernd; Halle, Martin

Medicine & Science in Sports & Exercise: May 2011 - Volume 43 - Issue 5 - p 18
doi: 10.1249/01.MSS.0000402720.41923.7b
B-17 Thematic Poster - Nutritional Antioxidants and Oxidative Stress: JUNE 1, 2011 1:00 PM - 3:00 PM: ROOM: 404

1Klinikum rechts der Isar, Technische Universitaet Muenchen, Munich, Germany. 2Appalachian State University, Kannapolis, NC.


(No relationships reported)

Strenuous exercise significantly increases the incidence of upper respiratory tract infections (URTI) caused by transient immune dysfunction. Naturally occurring polyphenolic compounds present in food such as non-alcoholic beer (NAB) have strong anti-oxidant, anti-pathogenic, and anti-inflammatory properties.

PURPOSE: To determine whether the ingestion of non-alcoholic beer polyphenols for three weeks prior to the Munich Marathon would attenuate post-race inflammation and decrease URTI incidence.

METHODS: Healthy male runners (N=277, age 42±9 y) were randomly assigned to 1-1.5 L/day NAB or placebo (PL) beverage (double-blinded design) for three weeks before and two weeks after the Munich Marathon. Blood samples were collected 4- and 1-week pre-race, and immediately-, 24-h-, and 72-h-post-race, and analyzed for inflammation measures (IL-6 and total blood leukocyte counts). URTI rates, assessed by the Wisconsin Upper Respiratory Symptom Survey (WURSS-21), were compared between groups during the 2-week period following the race.

RESULTS: Change in IL-6 was significantly reduced in NAB compared to PL immediately post-race [median (interquartile range): ng/L 23.9 (15.9 - 38.7) ng/L vs. 31.6 (18.5 - 53.3), p = 0.03]. Total blood leukocyte counts were also reduced in NAB versus PL by approximately 20% immediately- and 24-h-post-race (p=0.02). Incidence of URTI was 3.25-fold lower (95%-CI 1.38-7.66) (p=0.007) in NAB compared to PL during the 2-week post-marathon period.

CONCLUSION: Consumption of 1-1.5 L/day non-alcoholic beer for three weeks before and two weeks after marathon competition reduces post-race inflammation and URTI incidence.

© 2011 American College of Sports Medicine