D-56 Thematic Poster - Exercise Immunology: Inflammation, Nutrition: JUNE 2, 2011 3:15 PM - 5:15 PM: ROOM: 403
PURPOSE: Impaired wound healing of both acute and chronic wounds is a major health concern in obese and diabetic populations. Delayed wound healing rates in obesity are associated with increased tissue inflammation; therefore, therapies which reduce inflammation may be beneficial to the wound healing process. Exercise has been shown to reduce systemic and local inflammation in a variety of tissue types and to speed healing in aged mice and humans, which display impaired wound healing similar to obese individuals. We hypothesized that treadmill exercise (EX) would speed wound healing in diet-induced obese mice compared to non-exercised obese controls (SED).
METHODS: Mice were fed a 45% kcal from fat diet for 16 weeks, then treadmill exercised for 3 days prior and 5 days after application of a full-thickness dermal punch biopsy wound. Wounds were photographed daily and assessed for wound area via photoplanimetry.
RESULTS: EX sped healing in obese mice for the first 5 days post-wounding (p=0.05) and resulted in smaller wounds at days 1, 4, and 5 post-wounding (p<0.05). Additionally, the percentage of mice fully healed at day 12 post-wounding was higher in EX than in SED (p=0.009). There were no differences in body weight or food intake between EX and SED, either during the feeding or intervention phases of the study.
CONCLUSIONS: EX improves the wound healing rate in mice fed a high-fat diet. The finding that the majority of improvement in wound healing rate occurred during the first 5 days following wounding suggests a role for exercise in modulating the inflammatory response.