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Avenanthramide Supplementation in Older Women: Protection Against Exercise-Induced Inflammation: 589Board #6 1:00 PM - 3:00 PM

Koenig, Ryan T.; Dickman, Jonathan R.; Gao, Xiaojuan; Anderson, Jessica; Evans, Trent; Ji, Li Li FACSM

Medicine & Science in Sports & Exercise: May 2011 - Volume 43 - Issue 5 - p 18
doi: 10.1249/
B-17 Thematic Poster - Nutritional Antioxidants and Oxidative Stress: JUNE 1, 2011 1:00 PM - 3:00 PM: ROOM: 404

1University of Wisconsin-Madison, Madison, WI. 2Beijing Sport University, Beijing, China.


(No relationships reported)

Aging and eccentric exercise are associated with muscle inflammation, and aging is also associated with alterations in redox status. Oats contain a unique group of phytochemicals known as avenanthramides (AVA) that have been shown to decrease pro-inflammatory cytokine production and to serve as antioxidants.

PURPOSE: To investigate the effects of dietary AVA supplementation on the inflammatory and oxidative responses to downhill walking in post-menopausal women.

METHODS: Sixteen post-menopausal women aged 50-80 year were randomly assidgned to two groups, eating two 60-g cookies daily made with oat flour (50% by weight) containing either 152 mg AVA/kg (A) or 10.4 mg AVA/kg (C), for 8 wks. Before and after the supplementation period, subjects walked on a treadmill at 2.5 mph, -9% grade for four 15 min bouts with 5 min rest intervals. Blood samples were collected before and 24- and 48-h post exercise.

RESULTS: Plasma interleukin (IL)-1B concentration decreased in A vs. C, at rest and 24-h after exercise. IL-6 concentration was lower in A vs. C 48 h after exercise, and plasma C-reactive protein concentration was lower in A vs. C at 24- and 48-h post exercise following supplementation. Plasma Trolox-equivalent total antioxidant capacity increased following the supplementation period in A but not in C both at rest and after exercise.

CONCLUSIONS: Our data indicate that dietary AVA supplementation may decrease plasma inflammatory cytokine levels and increase antioxidant defense in post-menopausal women.

© 2011 American College of Sports Medicine