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The Effects Of A Natural Anti-inflammatory Product On Systemic Markers Of Inflammation Following Downhill Running: 2236Board #124 May 28 3:30 PM - 5:00 PM

Peters, Edith M.; Smith, Megan; Docrat, Aadil; Nadar, Anand; Chetty, Kovin; Passmore, Jo-Ann S.

Medicine & Science in Sports & Exercise: May 2009 - Volume 41 - Issue 5 - p 278
doi: 10.1249/01.MSS.0000355401.95790.36
D-30 Free Communication/Poster - Immunology: MAY 28, 2009 1:00 PM - 6:00 PM ROOM: Hall 4F
Free

1University of KwaZulu-Natal, Durban, South Africa. 2University of Cape Town, Cape Town, South Africa.

Email: futree@ukzn.ac.za

(E.M. Peters, Financial Support For Expenses Was Provided By Heel Pty South Africa. The Investigational Medicinal Products (Including Placebo) Were Provide By Heel GmbH Germany Without Charge., Ownership Interest.)

Traumeel, a natural anti-inflammatory preparation, is commonly used by athletes to reduce inflammatory response to exercise-induced muscle cell damage.

PURPOSE: To establish whether Traumeel, taken during five days before and three days following participation, attenuates exercise-induced systemic markers of the inflammatory response.

METHODS: After baseline laboratory and field testing, 24 healthy athletes (14 men and 10 women) were matched according to gender, BMI, training age and status, peak performance and foot strike patterns and randomised into Traumeel (TRS) and control (PLAC) groups in a placebo-controlled, double-blind design. One TRS or PLAC tablet was ingested 3 × per day for five days prior to and three days following a 90-minute exercise trial on a downhill (-6% gradient) at 75% VO2 max. Blood samples were collected prior to the 90-minute trial, immediately after the trial and 24 hours (24 PE), 48 hours and 72 hours following the trial. They were analysed for full blood count (FBC), serum creatine kinase (CK), lactate dehydrogenase (LDH), cortisol, C- reactive protein (CRP) and myeloperoxidase (MPO) and plasma interleukin (IL) -6, -8, -10 and -12p70 concentrations. Daily records of training and symptoms of delayed onset muscle soreness (DOMS) were kept during the trial period.

RESULTS: The 90-minute downhill running protocol resulted in significant elevations in mean circulating leukocyte, neutrophil, CK, LDH, cortisol, CPR, MPO, IL-6, IL-8 and IL-10 concentrations following both laboratory trials (p < 0.001). When comparing the TRS and PLAC groups, mean ± SD total and differential leukocyte count, CK, LDH, cortisol, CPR, MPO, cytokine concentrations did not differ (p > 0.05) over the five time points. At 24 PE, MPO concentrations were significantly higher (p = 0.04) in the TRS group (227.3 ± 130.7 ng/ml) than in the PLAC group (137.2± 71.9 ng/ml), while the severity of DOMS was lower in the TRS group throughout the three-day post-trial period.

CONCLUSIONS: The elevated MPO concentration at 24 PE provide preliminary novel evidence of enhanced activation of neutrophil oxidative burst activity following exercise-induced muscle damage which is hypothesized to accelerate the recovery process.

© 2009 American College of Sports Medicine