Share this article on:

Gene Expression and Heat Stroke: 1054:10 PM - 4:25 PM

Sonna, Larry A.; Sawka, Michael N. FACSM; Lilly, Craig M.

Medicine & Science in Sports & Exercise: May 2009 - Volume 41 - Issue 5 - p 16
doi: 10.1249/01.MSS.0000352728.75714.c8
B-44 Featured Science Session - Molecular Biology of Heat Stroke: Modern Approaches: WEDNESDAY, MAY 27, 2009 3:15 PM - 5:15 PM: ROOM: 616

1University of Maryland School of Medicine, Baltimore, MD.2USARIEM, Natick, MA.3University of Massachusetts, Worcester, Worcester, MA.

(No relationships reported)

Microarray analysis of gene expression has generated new insights into cellular responses to heat. Here we compare the results of three microarray studies performed on human peripheral blood mononuclear cells (PBMCs) in vitro and on samples obtained in vivo from (1) normal subjects performing exercise and (2) individuals who experienced exertional heat injury. A concept of overlapping component responses emerges from these comparisons, in which some of the gene expression changes that occur in PBMCs during exertional heat injury can be accounted for by normal cellular responses to heat, exercise, or both. Other gene expression changes after exertional heat illness appear to be specific to the disease state. If confirmed, these component responses might provide a better understanding of responses that are adaptive and those that are maladaptive in response to exercise and exercise-induced hyperthermia.

© 2009 American College of Sports Medicine