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C-42 Free Communication/Poster - Supplements I: MAY 28, 2009 7: 30 AM - 12: 30 PM ROOM: Hall 4F

Effects Of Fenugreek, Cinnamon, & Curcumin On Post Workout Inflammatory Response.

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Board #225 May 28 8:00 AM - 9:30 AM

Wilborn, Colin D.; Taylor, Lem W.; Foster, Cliffa A.; Swift, Trevor; Burken, Courtney; Florez, Maggie; Poole, Chris; Bushey, Brandon; Kreider, Richard B. FACSM; Willoughby, Darryn S. FACSM

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Medicine & Science in Sports & Exercise: May 2009 - Volume 41 - Issue 5 - p 227
doi: 10.1249/01.MSS.0000355249.80465.e6
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It has been documented that strenuous exercise suppresses cellular immunity leading to increased susceptibility to infections and delayed recovery. As mediators of these phenomena, cytokines released into the circulation have been a recent focus of attention.

PURPOSE: To assess the acute effectiveness of fenugreek, cinnamon, & curcumin on blunting inflammatory markers after muscle damage.

METHODS: Twenty healthy non-resistance trained male and female subjects were equally divided by gender and assigned to ingested either a proprietary blend of fenugreek, cinnamon, & curcumin (N = 10, 21 ± 2.8 yrs, 174 ± 10 in, 77 ± 20 kg) or placebo (N = 10, 20 ± 1.9 yrs 175 ± 14in, 89 ± 20 kg). Subjects ingested 450 mg of either active supplement (400mg fenugreek, 25mg cinnamon, 25mg curcumin) or 450 mg of placebo for 14 days prior to the damage bout. Subjects were instructed to warm-up briefly and subsequently perform 24 sets of 10 eccentric knee extensor repetitions with one leg at 30°/s on an isokinetic device. Subjects had their blood drawn at baseline, immediately post, 1hr, 3hr, and 24hr post damage. Serum samples were analyzed for IL 1b, IL1ra, IL6, TNFa and CRP levels using a multiplex bead based assay. Data were analyzed by a two-way ANOVA with repeated measures (p<0.05).

RESULTS: Significant (p<0.05) main effects for time were observed for the inflammatory markers IL 1b, IL1ra, & IL6, although there were no significant (p>0.05) interactions. However, a significant trend for interaction was observed for IL 6 (p=0.06) & IL1 ra (p = 0.09). Post hoc analysis revealed a significant difference immediately post damage in IL 1ra where active group was significantly lower than the placebo group (p<0.05) and a significant difference at 1hr & 3hr post damage IL6 where active was significantly lower (p<0.05) than placebo.

CONCLUSION: These results indicate that the protocol used induced significant (p<0.05) systemic inflammation. The experimental proprietary blend showed some positive anti-inflammatory effects as illustrated by a significantly (p<0.05) lower inflammatory response in IL1ra and IL 6 by 3hr post damage. It is concluded that fenugreek, cinnamon, and curcumin have potential anti-inflammatory properties and that they significantly reduced the onset of inflammation in response to muscle damage.

This study was funded by Indus Biotech.

© 2009 American College of Sports Medicine