E-38 Free Communication/Poster - Women's Health: Observational and Intervention Studies: MAY 29, 2009 7:30 AM - 12:30 PM ROOM: Hall 4F
PURPOSE: Sex steroids and sex hormone binding globulin (SHBG) have been used to predict cardiometabolic variables (CMV) associated with coronary heart disease risk and diabetes. Since waist circumference (WAIST) and visceral adipose tissue (VAT) are suitable anthropometric surrogates of CMV, this study was conducted to evaluate the contribution of androgens and SHBG to the prediction of CMV above that of WAIST and VAT.
METHODS: A total of 66 overweight/obese premenopausal Caucasian (CA) (n=36) and African-American (AA) (n=30) women interested in receiving weight management information, volunteered to participate in the study. All women were "apparently healthy" and none were taking any medications that would affect CMV. In addition to anthropometric measurements, serum samples were taken following an overnight fast to evaluate CMV.
RESULTS: Our findings showed that SHBG significantly predicted serum insulin (p= 0.003) insulin resistance (p= 0.006) and HDL2 (p= 0.011) above that of WAIST. In contrast, TT predicted many more variables above that of WAIST including: systolic (p= <0.001) and diastotic (p= <0.001) blood pressure (BP) total cholesterol (TChol) (p= 0.002) TChol/HDL cholesterol (p= 0.052) and Apo B (p= 0.002). Free testosterone using the Free Androgen Index (FAI) predicted the most CMV above WAIST including: systolic BP (p= 0.004) diastolic BP (p= 0.002) fasting insulin (p= 0.009) insulin resistance (p= 0.016) TChol (p= 0.035) HDL Cholesterol (p= 0.036) LDL Cholesterol (p= 0.029) and Apo B (p= 0.042). There was also a significant race by FAI interaction for serum glucose (p=0.029) with CA women showing a positive relationship between FAI and glucose above WAIST (r= 0.477; p= 0.004) and AA women showing no relationship (r= -0.074; p= 0.721). Substituting VAT for WAIST almost mirrored the results obtained using sex steroids and SHBG to predict CMV.
CONCLUSION: In contrast to SHBG, both TT and FAI contributed to numerous CMV above that of central obesity measures, thereby providing a more comprehensive evaluation of metabolic risk in overweight/obese CA and AA women. It should be noted, however, that FAI may not provide sufficient information regarding glucose status in AA women.