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The Influence Of Age On The Regulation Of Cerebral Blood Flow During Dynamic Exercise In Humans: 2322Board #1 June 1 3:30 PM −5:00 PM

Bezerra, Lídia A.; Merces, Luciana; Justino, Marco Aurélio; Guido, Marcelo; Alves, Vânia; de Melo, Helton Fabrício; de Oliveira, Ricardo Jacó; Fisher, James P.; Ogoh, Shigehiko; Raven, Peter B. FACSM; Fadel, Paul J.

Medicine & Science in Sports & Exercise: May 2007 - Volume 39 - Issue 5 - p S425
doi: 10.1249/01.mss.0000274681.30308.6e
F-19 Free Communication/Poster - Blood Flow and Tissue Oxygenation: JUNE 1, 2007 1:00 PM - 6:00PM ROOM: Hall E

1 University of Missouri, Columbia, MO.

2University of North Texas Health Science Center, Fort Worth, TX.

Catholic University of Brasília, Taguatinga Norte, Brazil. Email:


The aging process is being accompanied by decreasing in daily life activities. Hence, there is an increased risk of falls and fractures that provide morbidity and physical dependence. However the yoga practice has not been used to verify if it could improve the functional fitness in elderly women.

PURPOSE: To verify the effects of yoga practice in functional fitness in elderly women.

METHODS: A total of 29 women (63.9 ± 5.6 years old) was randomly screened and divided into two groups: Yoga Group (YG, n = 17) and Control Group (CG, n =12). The yoga practice lasted 4 months, 3 times/week/and 1 hour per session. The tests of 30-second chair stand, chair sit-and-reach, arm curl, 2-minute step test, back scratch and 8-foot up-and-go were performed before and after yoga training to assess the functional fitness. A Split Plot Anova was performed to analyze the results and the level of significance was p ≤ 0, 05.

RESULTS: There were significant increases between pre and post-test in the 2-minute step (64.7 ± 11.6 to 76.1 ± 11.3, no. of steps), arm curl (13.7 ± 3.1 to 17.7 ±4.3 no. of repetitions) and chair sit-reach tests (4.3 ± 5.2 to 9.9 ± 7.2, centimeters) in YG. Finally there was a significant decrease between-groups in the 8-Ft Up-Go test (6.3 ± 0.8 to 5.2 ± 0.5 and 5.8 ± 1.0 to 6, 6 ± 1, 0, seconds to YG and CG, respectively), and a significant increase between-groups in the 30-second chair stand test (11.3 ± 1.5 to 14.8 ± 2.4 and 14.7 ± 3.28 to 13.8 ± 2.6, no. of stands in YG and CG, respectively).

CONCLUSIONS: The yoga practice improved the functional fitness in elderly women.

PURPOSE: Although previous studies have indicated that cerebral autoregulation (CA) is well preserved in healthy older subjects under resting conditions, the influence of aging on the regulation of cerebral blood flow during dynamic exercise remains unclear. Therefore, this study was designed to determine middle cerebral artery blood flow velocity (MCA Vmean) and dynamic CA parameters during cycling in young and older middle-aged healthy humans.

METHODS: Heart rate (HR), mean arterial pressure (MAP), MCA Vmean and end tidal carbon dioxide tension (ETCO2) were measured at rest and during two 15 min bouts of cycling exercise performed at 30% and 50% heart rate reserve (HRR) in six young (25±2 yrs.) and six older middle-aged (57±5 yrs.) healthy subjects. Transfer function analysis between the changes in MAP and MCA Vmean in the low frequency range were used to assess dynamic cerebral autoregulation.

RESULTS: At rest, blood pressure and HR were similar between the older and younger subjects, whereas ETCO2 was significantly lower in the older subjects. More importantly, ETCO2 did not change from rest to exercise in the younger or older subjects. Exercise-induced increases in MAP were higher in the older subjects (104±3 mmHg young vs. 116±3 mmHg old at 50% HRR; p=0.003). Although MCA Vmean tended to increase in the younger and older subjects during dynamic exercise, this increase did not reach statistical significance and no differences were found between groups (young, 62±4 cm/s rest to 69±2 cm/s 50% HRR; old 65±3 cm/s rest to 71±4 cm/s 50% HRR; exercise effect p=0.121; age effect p=0.323). The normalized low frequency transfer function gain and phase shift between MAP and MCA Vmean were not different during dynamic exercise compared to rest in both groups.

CONCLUSIONS: In summary, changes in MCA Vmean and dynamic CA measures during dynamic exercise are not altered by aging. These preliminary findings suggest that the regulation of cerebral blood flow is well maintained during low and moderate dynamic exercise in healthy middle-aged subjects.

© 2007 American College of Sports Medicine