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Progressive Improvement in Glucose Tolerance with Light Resistance TVaining in Older Women: 1753Board #41 May 31 9:00 AM 10:30 AM

DiPietro, Loretta FACSM; Yeckel, Catherine W.; Dziura, James

Medicine & Science in Sports & Exercise: May 2007 - Volume 39 - Issue 5 - p S288
doi: 10.1249/01.mss.0000274112.76453.98
C-25 Free Communication/Poster- Carbohydrate Metabolism II: MAY 31, 2007 7:30 AM 12:30 PM ROOM: Hall E

The John B. Pierce Laboratory/Yale University, New Haven, CT. Email:

Supported by NIH/NIA RO1 AG17163 and MO 1 RR00125.

PURPOSE: To compare aerobic vs. light resistance training on serial improvements in glucose tolerance in aging.

METHODS: Healthy, inactive older (74 ± 5 (SD) y) women (N=20) were randomized into either a high volume/moderate-intensity aerobic (ATM: 240 min-wk-1; 65–75% VO2peak or 4.3 METs; n=12) or a lower-intensity resistance training (RTL; 180 min-wk-1; 50% VO2peak or 2.5 METs; n=8) control group. Both groups exercised under supervision 4 times per week for 45–60 min sessions over 9 months. Measurements of plasma glucose, insulin, and free fatty acid (FFA) responses to an oral glucose tolerance test (OGTT) were performed at baseline and at 3-, 6-, and 9-months 48 h after the last exercise session.

RESULTS: Surprisingly, we observed significant improvements in 2-h glucose concentrations at 3-, 6-, and 9-months among women in the RTL (152 ± 42 vs.134 ± 33 vs. 134 ± 24 vs. 130 ± 27mg-dL-1;p<0.05), butnot the ATM (151 ± 25 vs. 156 ± 37vs. 152 ± 40 vs. 155 ± 39 mg-dL-1) group. These improvements were accompanied by an 18% (p<0.07) decrease in basal FFA concentrations in the RTL group, whereas basal and 30-min FFA concentrations increased (p<0.05) after training in the ATM group.

CONCLUSIONS: These findings suggest that the net physiological benefit-to-stress ratio from exercise may have been lower in the ATM, compared with the RTL group, indicated by higher circulating levels of FFA after a large volume of moderate-intensity aerobic exercise, which may have temporarily interfered with insulin action.

© 2007 American College of Sports Medicine